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From Plant to Pathway: Molecular Mechanisms of Ruscogenin in Preventing Amyloid-Beta Aggregation through Computational and Experimental Approaches.
ACS Chem Neurosci
January 2025
Department of Bioengineering and Biotechnology, Birla Institute of Technology Mesra, Ranchi, Jharkhand 835215, India.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, extracellular amyloid-β (Aβ) plaque accumulation, and intracellular neurofibrillary tangles. Recent efforts to find effective therapies have increased interest in natural compounds with multifaceted effects on AD pathology. This study explores natural compounds for their potential to mitigate AD pathology using molecular docking, ADME screening, and assays, with ruscogenin─a steroidal sapogenin from emerging as a promising candidate.
View Article and Find Full Text PDFPreparation of Rare Dehydrated Protopanaxadiol Ginsenosides from Leaves by Confined Microwave-Driven Transformation.
J Agric Food Chem
January 2025
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, P.R. China.
Rare dehydrated ginsenosides barely exist in natural ginseng plants. Herein, the confined microwave technique was utilized to transform the main ginsenosides of leaves (PNL) into dehydrated ginsenosides. The main microwave-treated products of dried PNL are dehydrated ginsenoside Rk1, Rg5, notoginsenoside SFt3, and SFt4.
View Article and Find Full Text PDFEnrichment of Ginseng Rare Sapogenin 25-OH-PPT and Its Protective Effect on Myocardial Fibrosis.
Molecules
December 2024
School of Functional Food & Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Article Synopsis
- Ginseng contains rare compounds called ginsenosides, specifically 25-OH-PPT (T19), known for beneficial effects like lowering blood sugar and reducing inflammation.
- The research focused on optimizing the process to extract T19 from ginseng stems and leaves, utilizing different acids and hydrolysis conditions to maximize yield safely.
- Results showed that hydrochloric acid increased T19 content significantly, while citric acid was safer; additionally, T19 demonstrated protective effects on heart cells by reducing oxidative stress and impacting fibrosis markers.
Evaluation of inhibition and eradication of bacterial biofilm by solasodin.
J Steroid Biochem Mol Biol
December 2024
Laboratory of Microbiology and Molecular Biology - LMBM, Universidade Regional do Cariri - URCA, Crato 63105-000, Brazil; Department of Biological Chemistry, Universidade Regional do Cariri - URCA, Crato 63105-000, Brazil. Electronic address:
Biofilms are complex microbial structures that have a significant impact on human health, industry and the environment. These complex structures represent one of the main mechanisms of microbial resistance, and their development constitutes a serious health problem. Therefore, the aim of this study was to verify the potential for inhibition and eradication of bacterial biofilm by salosodine, which is a steroidal alkaloid sapogenin found in plants of the Solanum genus.
View Article and Find Full Text PDFSarsasapogenin stimulates angiogenesis and osteogenesis coupling to treat estrogen deficiency-induced osteoporosis by activating the GPX4/SLIT3/ROBO1 axis.
Phytomedicine
January 2025
School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China; Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China; Tongde Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310007, PR China; School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang 310007, PR China. Electronic address:
Article Synopsis
- The study investigates the potential of sarsasapogenin (SAR) to promote bone and blood vessel formation in postmenopausal osteoporosis, which is linked to estrogen deficiency and ferroptosis.
- SAR shows promise in enhancing cell survival and bone development while reducing cell death in tests with stem cells and blood vessel cells.
- Results indicate that SAR activates a signaling pathway involving SLIT3 and ROBO1, which is crucial for coupling bone growth and blood vessel formation, with GPX4 playing a key role in this process.
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