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Met58 and di-acidic motif located at C-terminal region of SARS-CoV-2 ORF6 plays a crucial role in its structural conformations.
Biophys Chem
December 2024
School of Biosciences and Bioengineering, Indian Institute of Technology Mandi, VPO Kamand, Himachal Pradesh, India. Electronic address:
Despite being mostly neglected in structural biology, the C-terminal Regions (CTRs) are studied to be multifunctional in humans as well as in viruses. Previously, SARS-CoV-2 Spike and NSP1 proteins' CTRs are observed to be disordered, and experimental evidence showed a gain of structure properties in different physiological environments. In this line, we have investigated the structural dynamics of CTR (residues 38-61) of SARS-CoV-2 ORF6 protein, disrupting bidirectional transport between the nucleus and cytoplasm.
View Article and Find Full Text PDFSmells like … no evidence that odors influence the attentional blink.
Atten Percept Psychophys
December 2024
Cognitive Psychology, Institute of Psychology, University of Hildesheim, Universitaetsplatz 1, D-31141, Hildesheim, Germany.
The attentional blink (AB) paradigm is frequently used to investigate temporal attention. Essentially, rapid serial visual streams of several distractors and two targets are presented. The accuracy in detecting the second target stimulus (T2) decreases in the time window between 100 and 500 ms following accurate detection of the first target stimulus (T1).
View Article and Find Full Text PDFExpert Opinions on Uveal Melanoma: Insights from the 58th Ophthalmic Oncology Group Meeting.
Ocul Oncol Pathol
December 2024
Ophthalmology Department, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Lausanne, Switzerland.
Introduction: Clear evidence for the best clinical management of uveal melanoma is lacking in some areas. Therefore, reports on expert opinions in the field can be valuable.
Methods: A questionnaire comprising 10 questions was distributed to potential participants of the 58th Ophthalmic Oncology Group Meeting in Stockholm, Sweden, in June 2024.
Herpes Simplex Keratitis Following Corneal Crosslinking for Keratoconus: A One-Year Case Series Follow-Up.
Diagnostics (Basel)
October 2024
Department of Ophthalmology, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, Croatia.
Corneal crosslinking (CXL) is a medical procedure used to treat keratoconus. CXL works by strengthening the collagen fibers of the cornea through the application of riboflavin (vitamin B2) and ultraviolet (UV) light, which helps to stabilize the cornea and prevent further deterioration. There is a recognized risk that CXL can trigger the reactivation of dormant herpes simplex virus (HSV), leading to herpetic keratitis even in patients with no history of herpetic disease.
View Article and Find Full Text PDFIntegrated Approach Using Intuitionistic Fuzzy Multicriteria Decision-Making to Support Classifier Selection for Technology Adoption in Patients with Parkinson Disease: Algorithm Development and Validation.
JMIR Rehabil Assist Technol
October 2024
Department of Productivity and Innovation, Universidad de la Costa CUC, 58th street #55-66, Barranquilla, 080002, Colombia, 57 3007239699.
Background: Parkinson disease (PD) is reported to be among the most prevalent neurodegenerative diseases globally, presenting ongoing challenges and increasing burden on health care systems. In an effort to support patients with PD, their carers, and the wider health care sector to manage this incurable condition, the focus has begun to shift away from traditional treatments. One of the most contemporary treatments includes prescribing assistive technologies (ATs), which are viewed as a way to promote independent living and deliver remote care.
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