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Ketamine induces multiple individually distinct whole-brain functional connectivity signatures.
Elife
April 2024
Department of Psychiatry, Yale University School of Medicine, New Haven, United States.
Background: Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it is unclear how ketamine's molecular mechanisms connect to its neural and behavioral effects.
Methods: We conducted a single-blind placebo-controlled study, with participants blinded to their treatment condition.
Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD.
Elife
July 2021
Department of Psychiatry, Yale University, New Haven, United States.
Psychoactive drugs can transiently perturb brain physiology while preserving brain structure. The role of physiological state in shaping neural function can therefore be investigated through neuroimaging of pharmacologically induced effects. Previously, using pharmacological neuroimaging, we found that neural and experiential effects of lysergic acid diethylamide (LSD) are attributable to agonism of the serotonin-2A receptor (Preller et al.
View Article and Find Full Text PDFDelayed amnesic syndrome after riluzole use in major depressive disorder: a case report.
Psychosomatics
April 2014
Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA.
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