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Endogenous tagging of multiple cellular components in the sea anemone .
Proc Natl Acad Sci U S A
January 2023
Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.
The cnidarian has developed into a powerful model system to study the mechanisms underlying animal development, regeneration, and evolution. However, despite the significant progress in the molecular and genetic approaches in this sea anemone, endogenous protein tagging is still challenging. Here, we report a robust method for knock in for using CRISPR/Cas9.
View Article and Find Full Text PDFPrimary central nervous system sarcomas in adults: A systematic review.
Clin Neurol Neurosurg
March 2022
Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Background: Primary central nervous system (CNS) sarcomas represent a heterogeneous group of rare neoplasms with unclear etiology. Available data on clinical characteristics, treatment strategies, and survival are scarce. We comprehensively reviewed management strategies and outcomes of primary CNS sarcomas in adults.
View Article and Find Full Text PDFSystemic involvement in mycosis fungoides.
Clin Dermatol
June 2016
Department of Dermatology, University of Zurich, Switzerland. Electronic address:
Mycosis fungoides (MF) represents almost 50% of all primary cutaneous lymphomas and more than 70% of cutaneous T-cell lymphomas (CTCL). Arising from preferentially skin-homing lymphocytes with genetic instability, MF evolves through stages (IA-IVB), producing inconspicuous inflammatory features in the beginning and finally resulting in a proliferation of cytomorphologic, phenotypic, and genotypic abnormal tumor cells. Over the past 200 years, there has been much confusion in the classification of lymphomas due to semantic disagreements (MF, CTCL, parapsoriasis, lymphosarcoma, reticulum cell sarcoma, and many other terms), lack of diagnostic standard criteria, and new molecular diagnostic methods.
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