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To kill or to piggyback: Switching of viral lysis-lysogeny strategies depending on host dynamics.
Sci Total Environ
December 2024
Archaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen 518055, PR China. Electronic address:
Viruses wield significant influence over microbial communities and ecosystem function in marine environments. However, the selection of viral life strategies and their impacts on microbial communities remains enigmatic. In this study, we utilized a large-scale macrocosm, established using water samples from a marine coastal region, to enable community-level investigation.
View Article and Find Full Text PDFTemperate phage-antibiotic synergy is widespread-extending to -but varies by phage, host strain, and antibiotic pairing.
mBio
December 2024
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Unlabelled: Bacteriophages (phages) are bacterial-specific viruses that can be used alone or with antibiotics to reduce bacterial load. Most phages are unsuitable for therapy because they are "temperate" and can integrate into the host genome, forming a lysogen that is protected from subsequent phage infections. However, integrated phages can be awakened by stressors such as antibiotics.
View Article and Find Full Text PDFHost-specific viral predation network on coral reefs.
ISME J
January 2024
Department of Biology, University of Miami, Coral Gables, FL 33146, United States.
Viral infections are major modulators of marine microbial community assembly and biogeochemical cycling. In coral reefs, viral lysis controls bacterial overgrowth that is detrimental to coral health. However, methodological limitations have prevented the identification of viral hosts and quantification of their interaction frequencies.
View Article and Find Full Text PDFFine-tuned spatiotemporal dynamics of DNA replication during phage lambda infection.
J Virol
November 2024
Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA.
Unlabelled: After the ejection of viral DNA into the host cytoplasm, the temperate bacteriophage (phage) lambda integrates a cascade of expressions from various regulatory genes, coupled with DNA replication, to commit to a decision between lysis and lysogeny. Higher multiplicity of infection (MOI) greatly shifts the decision toward the lysogenic pathway. However, how the phage separates the MOI from replicated viral DNA during lysis-lysogeny decision-making is unclear.
View Article and Find Full Text PDFDeciphering the Genetic Architecture of Prophage vB_G30_01: A Comprehensive Molecular Analysis.
Viruses
October 2024
College of Land and Environment, Shenyang Agricultural University, Shenyang 110866, China.
The current knowledge of phages is limited, with few genomes sequenced and characterized. In this study, a prophage, vB_G30_01, isolated from G30 was characterized and evaluated for its lysogenic host range. The phage was studied using transmission electron microscopy and a host range.
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