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Does high body mass index (>25 kg/m) or weight (>80 kg) reduce the effectiveness of anti-D prophylaxis in Rh(D)-negative pregnant women? A systematic review and meta-analysis.
Vox Sang
September 2024
Thrombosis and Vascular Diseases Laboratory, School of Health and Biomedical Sciences, STEM College, RMIT University, Bundoora, Victoria, Australia.
Background And Objectives: Haemolytic disease of the foetus and newborn (HDFN) occurs when maternal antibodies, often triggered by foetal antigens, destroy foetal and neonatal red blood cells. Factors like antibody strength, quantity and gestational age influence HDFN severity. Routine antenatal anti-D prophylaxis (RAADP) has significantly reduced HDFN cases.
View Article and Find Full Text PDFPseudolymphomatous Cutaneous Angiosarcoma Presenting With Persistent Firm Facial Edema in a Patient With Systemic Sclerosis.
Am J Dermatopathol
September 2024
Rheumatology Department, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Ciudad de Mexico, México.
Article Synopsis
- Pseudolymphomatous cutaneous angiosarcoma (cAS) is a rare cancer that can be difficult to diagnose due to its similarity to other lymphoid conditions, showcasing notable lymphocyte presence.
- A unique case involving a 47-year-old woman with systemic sclerosis (SSc) is presented, characterized by facial swelling and specific imaging findings that led to a skin biopsy showing unusual vascular patterns and dense lymphocyte growth.
- This case highlights the connection between SSc and higher cancer risk, emphasizing the diagnostic challenges of cAS and the need for early detection and comprehensive management strategies.
Mesenchymal and Vascular Dissemination Markers, Erythroblastosis Virus E26 Oncogene Homolog (ERG) and Alpha Smooth Muscle Actin (α-SMA), in Colorectal Cancer and Adjacent Tissue, Pericytes or Microvascular Density.
Cureus
December 2023
Department of Pathology, College of Medicine, University of Duhok, Duhok, IRQ.
The harmony between malignant cells and the adjacent microenvironment is a sophisticated subject; however, it seems to play an important role in cancer evolution. This study aimed to assess the microvascular density (MVD) and the mean pericyte number in the tumor and adjacent tissue, and to correlate the results with special histopathological prognostic variables of the tumor. The study included 48 colorectal cancer (CRC) cases diagnosed in the central lab of Duhok.
View Article and Find Full Text PDFHow do we perform intrauterine transfusions?
Transfusion
December 2023
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Background: Intrauterine transfusion (IUT) is an invasive but critical and potentially life-saving intervention for severe fetal anemia with demonstrated improvement in outcomes. The fetus is vulnerable to hemodynamic alterations and transfusion-related adverse events; therefore, special consideration must be given to blood component selection and modification. There is widespread IUT practice variability, and existing guidance primarily relies on expert opinion and single center experiences.
View Article and Find Full Text PDFComparison of prenatal anti-D titration testing by gel and tube methods: A review of the literature.
Transfusion
June 2021
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
Background: Antenatal titration testing is traditionally performed using a manual tube test. Tube testing has limitations; it is a manual, time-consuming method with wide interobserver variability. Gel-based testing is an attractive alternative because it is more precise and can be automated.
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