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| http://dx.doi.org/10.1136/hrt.14.4.470 | DOI Listing |
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An Unusual Presentation of Cutaneous Bullous Lupus.
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Rheumatology, Cooper University Health Care, Camden, USA.
Drug-induced lupus erythematosus (DILE) is an autoimmune reaction that results in symptoms of polyarthralgia, fever, and cutaneous lesions and other manifestations. Several drugs have been documented to cause this disease, including procainamide, isoniazid, methyldopa, penicillamine, and hydralazine. Systemic lupus erythematosus (SLE) manifestations often occur after the patient has been taking the drug without complications for months to years.
View Article and Find Full Text PDFCarbamazepine treatment of myotonia congenita in a cat.
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Neurology and Neurosurgery, Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
Case Summary: A 2-year-old female intact domestic shorthair cat was referred to the neurology service at the Foster Hospital for Small Animals as a result of lifelong weakness, seizure-like episodes after excitement, muscle spasms, stiffness of the limbs and shortness of breath. A diagnosis of myotonia congenita (MC) was made based on compatible history, clinical signs and electromyography findings, and excluding other causes of muscle weakness using muscle biopsy, baseline bloodwork and echocardiography. Initial treatment with procainamide had overall low efficacy.
View Article and Find Full Text PDFCellulose functionalized magnetic beads for high throughput glycosylation analysis in biotherapeutic modalities.
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Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore, 138668, Republic of Singapore.
The increasing demand for biotherapeutics has necessitated the evaluation of their critical quality attributes, one of which is glycosylation, an essential post-translational modification found on many biological molecules. In particular, the purification of N-glycans after their release from the proteins and derivatization is important in ensuring the removal of the deglycosylated protein, excess labelling reagents and salts for subsequent analysis. However, current methods of N-glycans purification are either expensive, laborious, time-consuming or not catered for high throughput analysis.
View Article and Find Full Text PDFDrug-Induced Systemic Lupus Erythematosus: A Rare Presentation of Hydralazine-Induced Lupus.
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Internal Medicine, Arrowhead Regional Medical Center, Colton, USA.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by the production of autoantibodies directed against nuclear and cytoplasmic antigens. SLE can be induced by various medications, such as hydralazine, procainamide, isoniazid, methyldopa, chlorpromazine, quinidine, and minocycline. Hydralazine-induced lupus syndrome was first reported in 1953, and only occurs in 5-10% of patients taking hydralazine.
View Article and Find Full Text PDFComparison of Oral Procainamide and Mexiletine Treatment of Recurrent and Refractory Ventricular Tachyarrhythmias.
J Clin Med
October 2024
Division of Cardiology, University Hospital "S.Maria della Misericordia", P.le S.Maria della Misericordia 15, 33100 Udine, Italy.
Article Synopsis
- The study investigates the effectiveness and tolerability of oral procainamide versus mexiletine for treating recurrent ventricular arrhythmias in patients who didn't respond to standard therapies like amiodarone and beta-blockers.
- Out of 68 patients treated, approximately 56% experienced a significant reduction in arrhythmia burden, with procainamide showing nearly three times higher efficacy compared to mexiletine.
- Side effects were noted in both treatments, but procainamide had a lower discontinuation rate due to severe side effects, suggesting it may be a preferable option for this patient group.
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