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Lipoic acid improves wound healing through its immunomodulatory and anti-inflammatory effects in a diabetic mouse model.
J Diabetes Metab Disord
June 2025
Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh, 11623 Saudi Arabia.
Objectives: Diabetes mellitus is a chronic disease that has become more prevalent worldwide because of lifestyle changes. It leads to serious complications, including increased atherosclerosis, protein glycosylation, endothelial dysfunction, and vascular denervation. These complications impair neovascularization and wound healing, resulting in delayed recovery from injuries and an elevated risk of infections.
View Article and Find Full Text PDFSympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of Oxytocin (OT)-elicited reductions of body weight gain and adiposity in male diet-induced obese rats.
Front Drug Deliv
December 2024
VA Puget Sound Health Care System, Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, WA 98108, USA.
Recent studies indicate that central administration of oxytocin (OT) reduces body weight (BW) in high fat diet-induced obese (DIO) rodents by reducing energy intake and increasing energy expenditure (EE). Previous studies in our lab have shown that administration of OT into the fourth ventricle (4V; hindbrain) elicits weight loss and stimulates interscapular brown adipose tissue temperature (T) in DIO rats. We hypothesized that OT-elicited stimulation of sympathetic nervous system (SNS) activation of IBAT contributes to its ability to activate BAT and reduce BW in DIO rats.
View Article and Find Full Text PDFPropagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson's disease.
Nat Neurosci
January 2025
Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
Article Synopsis
- The aggregation of α-synuclein (α-Syn) in peripheral organs, particularly the kidneys, is suggested to initiate the spread of Lewy body diseases (LBDs) like Parkinson's disease (PD) to the brain.
- Research indicates that chronic renal failure may lead to increased α-Syn deposits in both the kidneys and brain of affected individuals, possibly explaining the higher incidence of PD in these patients.
- Experiments in mice show that the kidney plays a role in clearing α-Syn from the blood, and renal damage can enhance its deposition in the kidney and subsequent propagation to the brain, highlighting the kidney's potential role in the pathogenesis of LBDs.
Electrophysiological Abnormalities in Finger Extension Weakness and DOwnbeat Nystagmus Motor Neuron Disease: Three New Patients and Review of the Literature.
Muscle Nerve
January 2025
Service ENMG et de Pathologies Neuromusculaires, Centre de référence Des Maladies Neuromusculaires PACA-Réunion-Rhône Alpes, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France.
Introduction/aims: Finger Extension Weakness and DOwnbeat Nystagmus Motor Neuron Disease (FEWDON-MND) is characterized by motor weakness predominantly affecting finger extension, accompanied by downbeat nystagmus. To date, only 11 patients have been reported. The present study adds a further three and aims to provide a more detailed description of the electrodiagnostic features of these patients.
View Article and Find Full Text PDFBehavioral adaptations after unilateral whisker denervation.
Behav Brain Res
January 2025
Neuroscience Program, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Electronic address:
Article Synopsis
- The rodent whisker system is a useful model for studying how experience affects changes in brain structure, neural connections, and behavior.
- Unilateral whisker denervation alters whisker circuits but does not significantly change how adult mice navigate open spaces or perform in object localization tasks, though it does affect their ability to cross gaps.
- Chronic whisker denervation results in heightened anxiety-like behaviors, which can be mitigated through training on a specific task involving gap crossing, suggesting that mice adapt their behavior when faced with sensory limitations.
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