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Advancing High-Throughput Cellular Atomic Force Microscopy with Automation and Artificial Intelligence.
ACS Nano
January 2025
Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France.
Atomic force microscopy (AFM) has reached a significant level of maturity in biology, demonstrated by the diversity of modes for obtaining not only topographical images but also insightful mechanical and adhesion data by performing force measurements on delicate samples with a controlled environment (e.g., liquid, temperature, pH).
View Article and Find Full Text PDF[Digital pathology using ex vivo confocal laser scanning microscopy].
Dermatologie (Heidelb)
January 2025
Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, München, Deutschland.
Ex vivo confocal laser scanning microscopy (EVCM) is a novel diagnostic method for bedside use with the possibility to perform rapid dermatopathological examinations on fresh tissue, while directly creating digital pictures. The aim of this article is to provide an overview of current study results in the field of EVCM. Due to the large number of studies in dermatology, the focus is set on the diagnosis of dermatological diseases.
View Article and Find Full Text PDFResistance-breaking strains of tomato spotted wilt virus hamper photosynthesis and protein synthesis pathways in a virus accumulation-dependent manner in Sw5-carrying tomatoes.
Sci Rep
January 2025
Istituto per la Protezione Sostenibile delle Piante, Consiglio Nazionale delle Ricerche, via Amendola 165/A, 70126, Bari, Italy.
Tomato spotted wilt virus (TSWV; Orthotospovirus tomatomaculae) is one of the major horticultural threats due to its worldwide distribution and broad host range. In Italy, TSWV is widely spread in tomato (Solanum lycopersicum) crops and causes severe yield losses. In the last decades, several tomato varieties carrying the Sw-5b gene for resistance to TSWV have been released.
View Article and Find Full Text PDFCompositIA: an open-source automated quantification tool for body composition scores from thoraco-abdominal CT scans.
Eur Radiol Exp
January 2025
Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Background: Body composition scores allow for quantifying the volume and physical properties of specific tissues. However, their manual calculation is time-consuming and prone to human error. This study aims to develop and validate CompositIA, an automated, open-source pipeline for quantifying body composition scores from thoraco-abdominal computed tomography (CT) scans.
View Article and Find Full Text PDFDynamic simulation of breast behaviour during different activities based on finite element modelling of multiple components of breast.
Sci Rep
January 2025
School of Fashion and Textiles, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
This study presents an advanced dynamic finite element (FE) model of multiple components of the breast to examine the biomechanical impact of different types of physical activities and activity intensity on the breast tissues. Using 4D scanning and motion capture technologies, dynamic data are collected during different activities. The accuracy of the FE model is verified based on relative mean absolute error (RMAE), and optimal material parameters are identified by using a validated stepwise grid search method.
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