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Transcriptomic and biochemical analysis of the mechanism of sodium gluconate promoting the degradation of benzo [a] pyrene by Bacillus subtilis MSC4.
J Environ Sci (China)
June 2025
School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China; Guangdong Key Laboratory of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou 510006, China. Electronic address:
Article Synopsis
- - Benzo[a]pyrene (B[a]P) is a harmful environmental pollutant that can enter the human body through food, making its remediation crucial.
- - This study shows that using Sodium gluconate as a biostimulant with the bacterium Bacillus subtilis MSC4 enhances the degradation of B[a]P by increasing biomass and gene expression related to its breakdown.
- - The research highlights various metabolic enhancements, including up-regulated genes linked to carbon metabolism, nitrogen cycling, and nutrient transport, which collectively improve the effectiveness of B[a]P degradation.
Systems biology of electrogenic Pseudomonas putida - multi-omics insights and metabolic engineering for enhanced 2-ketogluconate production.
Microb Cell Fact
September 2024
Institute of Systems Biotechnology, Saarland University, Saarbrücken, Germany.
Background: Pseudomonas putida KT2440 has emerged as a promising host for industrial bioproduction. However, its strictly aerobic nature limits the scope of applications. Remarkably, this microbe exhibits high bioconversion efficiency when cultured in an anoxic bio-electrochemical system (BES), where the anode serves as the terminal electron acceptor instead of oxygen.
View Article and Find Full Text PDFDeletion of p38 MAPK in macrophages ameliorates peritoneal fibrosis and inflammation in peritoneal dialysis.
Sci Rep
September 2024
Department of Nephrology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto, 6068507, Japan.
One of the most common causes of peritoneal dialysis withdrawal is ultrafiltration failure which is characterized by peritoneal membrane thickening and fibrosis. Although previous studies have demonstrated the inhibitory effect of p38 MAPK inhibitors on peritoneal fibrosis in mice, it was unclear which specific cells contribute to peritoneal fibrosis. To investigate the role of p38 MAPK in peritoneal fibrosis more precisely, we examined the expression of p38 MAPK in human peritoneum and generated systemic inducible p38 MAPK knockout mice and macrophage-specific p38 MAPK knockout mice.
View Article and Find Full Text PDFThe mitigating effects and mechanisms of Bacillus cereus on chronic cadmium poisoning in Litopenaeus vannamei based on histopathological, transcriptomic, and metabolomic analyses.
Ecotoxicol Environ Saf
October 2024
College of Fisheries, Guangdong Ocean University, Zhanjiang, Guangdong 524088, China. Electronic address:
Shrimp are non-negligible victims of cadmium (Cd) contamination, and there is still a lack of strategies for mitigating Cd toxicity in shrimp. Bacillus cereus, with its significant heavy metal (HM) tolerance and chelating effects, is a representative beneficial bacterium to be investigated for mitigating the toxicity of Cd exposure. This study revealed the effects and potential mechanisms of B.
View Article and Find Full Text PDFZinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation.
Biomed Pharmacother
August 2024
Department of Dermatology, Huazhong University of Science and Technology Tongji Medical College Tongji Hospital, Wuhan, China. Electronic address:
Article Synopsis
- Atopic dermatitis (AD) is a long-term inflammatory skin condition influenced by immune factors, and a study explored the relationship between serum trace elements, particularly zinc, and the condition's development.
- Analysis revealed that AD patients had lower zinc levels and showed an increased expression of the gene CXCL10 in their skin, suggesting a direct link between these factors.
- Treatment with zinc gluconate not only reduced CXCL10 release but also improved skin conditions in a mouse model of AD, indicating its potential as a targeted therapy for managing the disorder.
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