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Mastocytosis is a group of disorders characterized by the pathologic accumulation of mast cells in various tissues. One example of mastocytosis is urticaria pigmentosa, which presents with mastocytomas that can cause hives and, when irritated, pruritus. To our knowledge, we are describing the first case of urticaria pigmentosa without pruritus.
View Article and Find Full Text PDFBullous Mastocytosis: A Rare Variant of Diffuse Cutaneous Mastocytosis.
Cureus
January 2024
Dermatopathology, International Dermpath Consult, Dubai, ARE.
Mastocytosis is a disease of the mast cells caused by an increase in the number of mast cells due to abnormal proliferation. The disease is associated with a mutation in the gene, which is a key factor in the development of mast cells. Mastocytosis is classified into two main groups, namely, cutaneous and systemic mastocytosis, based on the site of mast cell accumulation.
View Article and Find Full Text PDFChallenges in the Diagnosis of Cutaneous Mastocytosis.
Diagnostics (Basel)
January 2024
St John's Institute of Dermatology, Guy's Hospital, London SE1 9RT, UK.
Background: Mastocytosis is characterized by an accumulation of clonal mast cells (MCs) in tissues such as the skin. Skin lesions in mastocytosis may be clinically subtle or heterogeneous, and giving the correct diagnosis can be difficult.
Methods: This study compiles personal experiences together with relevant literature, discussing possible obstacles encountered in diagnosing skin involvement in mastocytosis and cutaneous mastocytosis (CM).
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