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Can chick meconium serve as a source of biomarkers linked to hatchling quality and the age of parent stock?
Poult Sci
December 2024
Postgraduate Program in Veterinary Sciences, Faculty of Veterinary Medicine, Federal University of Uberlândia, Brazil; Postgraduate Program in Genetics and Biochemistry, Federal University of Uberlândia, Brazil.
One possible approach to selecting chicks based on quality involves identifying biomarkers in biological samples. Concurrently, understanding the metabolic profile of chicks from different-aged breeders is essential for developing strategies to mitigate the age-related effects on hatchability. This study investigated whether chick quality and breeder age influence the metabolic profile of layer chick meconium.
View Article and Find Full Text PDFImprovement of bone properties in children with osteogenesis imperfecta after pamidronate: a bone biopsy study.
JBMR Plus
February 2025
INSERM UMR 1033, Univ Lyon, Université Claude Bernard Lyon 1, F-69008 Lyon, France.
OI, or bone brittle disease, is characterized by increased mineralization of bone matrix independently of clinical severity. So, a beneficial effect of antiresorptive treatments such as bisphosphonates (BP) is questionable. We aim to compare the bone matrix characteristics before and after BP pamidronate (PAM).
View Article and Find Full Text PDFExploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome- paving the path towards precision medicine: a case report.
J Cancer Res Clin Oncol
January 2025
Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany.
Background: Li-Fraumeni syndrome (LFS) is an autosomal dominant tumor predisposition syndrome characterized by a high familial incidence of various malignancies. It results from pathogenic/likely pathogenic heterozygous constitutional variants of the TP53 gene. Due to impaired DNA damage repair, conventional cytotoxic therapies or radiotherapy should be avoided whenever feasible to mitigate the high incidence of treatment-related secondary malignancies in these patients.
View Article and Find Full Text PDFStackDILI: Enhancing Drug-Induced Liver Injury Prediction through Stacking Strategy with Effective Molecular Representations.
J Chem Inf Model
January 2025
Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 2001 Longxiang Road, 518172 Shenzhen, China.
Drug-induced liver injury (DILI) is a major challenge in drug development, often leading to clinical trial failures and market withdrawals due to liver toxicity. This study presents StackDILI, a computational framework designed to accelerate toxicity assessment by predicting DILI risk. StackDILI integrates multiple molecular descriptors to extract structural and physicochemical features, including the constitution, pharmacophore, MACCS, and E-state descriptors.
View Article and Find Full Text PDFSynthesis of zinc oxide/bismuth oxide nanocomposite photocatalyst for visible light-assisted degradation of synthetic dyes and antibacterial application.
Environ Sci Pollut Res Int
January 2025
School of Applied Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha, India.
Contamination of water resources by artificial coloring agents and the increasing incidence of bacterial illnesses are two significant environmental and public health issues that are getting worse day by day. Traditional treatment techniques frequently fail to address these problems adequately in a sustainable and environmental friendly way. In response, our study presents a novel photocatalyst that demonstrates superior photodegradation capability and antibacterial qualities in catering the above issues.
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