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An integrative review on the risk factors, prevention, and control strategies for carbapenem-resistant colonization in critically ill patients.
Front Microbiol
January 2025
Department of Critical Care Medicine, Qilu Hospital, Shandong University, Jinan, China.
The presence of carbapenem-resistant (CR) has become one of the leading causes of life-threatening, hospital-acquired infections globally, especially with a notable prevalence in intensive care units (ICUs). The cross-transmission of microorganisms between patients and the hospital setting is crucial in the development of CR colonization and subsequent infections. Recent studies indicate that colonization typically precedes infection, suggesting the effectiveness and necessity of preventing CR colonization as a primary method to lower infection risks.
View Article and Find Full Text PDFDevelopment of a SYBR Green-based RT-qPCR assay for the rapid detection of peste-des-petits-ruminants virus.
J Vet Diagn Invest
January 2025
Departments of Veterinary Microbiology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Kerala, India.
Peste-des-petits-ruminants (PPR) is primarily a disease of small ruminants caused by peste-des-petits-ruminants virus (PPRV; , ), formerly the small ruminant morbillivirus. PPRV can cause significant morbidity and mortality in small ruminants and a significant economic impact. Conventional reverse-transcription PCR (RT-PCR), and probe-based and SYBR Green-based RT quantitative real-time PCR (RT-qPCR), are employed for the molecular detection of PPRV.
View Article and Find Full Text PDFAsymmetric Organocatalytic 1,6-Conjugate Addition of Alkynyl 8-Methylenenaphthalen-2(8)-one Formed In Situ: Synergistic Construction of Axial and Central Chirality.
Org Lett
January 2025
Taizhou Research Institute, Southern University of Science and Technology, Taizhou 318014, Zhejiang, China.
Organocatalytic enantioselective formal nucleophilic substitution reactions of α-(2-hydroxynaphthalen-8-yl)propargyl alcohols with 1-(1-indol-3-yl)naphthalen-2-ols have been established for the first time. With the aid of a suitable chiral phosphoric acid, alkynyl 8-methylenenaphthalen-2(8)-one was formed in situ from the corresponding α-(2-hydroxynaphthalen-8-yl)propargyl alcohol, followed by enantioselective 1,6-conjugate additions of 1-(1-indol-3-yl)naphthalen-2-ols to afford a number of enantioenriched (,)-2,3-disubstituted indoles in 50-80% yields with 81-93% ee and (,)-2,3-disubstituted indoles in 18-40% yields with 79-96% ee. Notably, these nucleophilic substitution products were characterized by the presence of functional groups, including indole, naphthol, and alkynyl units, while exhibiting both axial and central chirality.
View Article and Find Full Text PDFNovel Rhamnose-Containing Glycopolymers from the Cell Wall of VKM Ac-1390.
Biochemistry (Mosc)
December 2024
Pushchino Scientific Center for Biological Research, Russian Academy of Sciences, Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino, Moscow Region, 142290, Russia.
VKM Ac-1390 (family Microbacteriaceae, class Actinomycetes) contains three rhamnose-containing glycopolymers in the cell wall, the structures of which were established by chemical and NMR spectroscopy methods. The first polymer, a rhamnomannan, consists of repeating tetrasaccharide units with xylopyranose side residues, →2)-α-[β-D-Xyl-(1→3)]-D-Rha-(1→3)-α-D-Man-(1→2)-α-D-Rha-(1→3)-α-D-Man-(1→. The second polymer found in minor amounts, is a rhamnan, →2)-α-D-Rha-(1→3)-α-D-Rha-(1→.
View Article and Find Full Text PDFPredicting early diagnosis of intensive care unit-acquired weakness in septic patients using critical ultrasound and biological markers.
BMC Anesthesiol
January 2025
Department of Critical Care Medicine, West China Hospital, Sichuan University, 37 Guo Xue Xiang St, Chengdu, 610041, Sichuan, China.
Objective: Early diagnosis of intensive care unit-acquired weakness (ICUAW) is crucial for improving the outcomes of critically ill patients. Hence, this study was designed to identify predisposing factors for ICUAW and establish a predictive model for the early diagnosis of ICUAW.
Methods: This prospective observational multicenter study included septic patients from the comprehensive ICUs of West China Hospital of Sichuan University and 10 other hospitals between September and November 2023.
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