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Age exacerbates the negative effect of depression on executive functioning in racial and ethnic minorities.
Brain Imaging Behav
October 2024
Department of Psychology, University of Texas at Austin, 108 Dean Keeton Street, Austin, TX, 78712, USA.
Age and depression may interact to produce a "double jeopardy" for cognitive impairment, and executive functioning, in cognitively unimpaired aging. Few studies have considered middle age or the ethnoracial diversity of subjects, despite evidence of more severe cognitive outcomes in historically minoritized people. In this pilot study, we investigated the impact of age on depression-related cognitive impairment and the underlying brain volumes in middle-aged non-Hispanic White adults (116), and Hispanic and Black adults (60), with a total number of 176 adults.
View Article and Find Full Text PDFQuality of Life in Older Adults With Stable Ischemic Heart Disease and Diabetes Mellitus: A Post Hoc Analysis of the BARI 2D Trial.
Am J Cardiol
July 2024
Inova Center of Outcomes Research, Falls Church, Virginia; Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:
Article Synopsis
- The study examines the long-term quality-of-life (QoL) outcomes for older adults (65+) with stable ischemic heart disease (SIHD) and diabetes after different treatment methods: intensive medical therapy (IMT) alone, revascularization (PCI or CABG) with optimal medical therapy (OMT).
- A total of 929 patients were analyzed over five years, revealing no significant differences in QoL metrics such as self-health score and Duke activity status index (DASI) between those who underwent PCI or CABG compared to those who received IMT alone.
- The findings suggest that both treatment approaches lead to similar QoL outcomes, highlighting the need for more targeted research in older adults regarding SIHD treatment, especially
Emergency Nurses' Reasons for Not Recommending Their Hospital to Clinicians as a Good Place to Work.
JAMA Netw Open
April 2024
Center for Health Outcomes and Policy Research, School of Nursing, University of Pennsylvania, Philadelphia.
Importance: Half of emergency nurses report high burnout and intend to leave their job in the next year. Whether emergency nurses would recommend their workplace to other clinicians may be an important indicator of a hospital's ability to recruit clinicians.
Objective: To examine why emergency nurses do not recommend their hospital to other clinicians as a good place to work.
Impact of Incomplete Revascularization After PCI in Left Main Disease: The EXCEL Trial.
Circ Cardiovasc Interv
March 2024
The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.W.S.).
Article Synopsis
- - The study examined how complete revascularization after percutaneous coronary intervention (PCI) impacts patients with left main coronary artery disease, using data from the EXCEL trial involving 903 patients over a 5-year follow-up.
- - Findings showed that the risk of death or myocardial infarction (MI) did not significantly differ based on traditional measures of complete revascularization but was notably higher with a higher residual Jeopardy Score (rJS), particularly for patients with untreated severe stenoses in the left circumflex artery (LCX).
- - Specifically, patients with an rJS of 4 or more had worse outcomes, with increased mortality and spontaneous MI, highlighting the importance of addressing untreated high-grade lesions post-PCI for
Mesenchymal stem cells enhance targeted bone growth from injectable hydrogels with BMP-2 peptides.
J Orthop Res
July 2024
Department of Biomedical Engineering, Rowan University, Glassboro, New Jersey, USA.
Osteoporosis is the most common chronic metabolic bone disease, and the prevalence of osteoporotic fractures is rapidly increasing with the aging population. While bisphosphonates can reduce bone loss and risk of fracture, these drugs are systemic, rely on long-term use, and patient compliance is low. Recombinant human bone morphogenetic protein-2 (BMP-2) is an FDA-approved protein that can offer a more targeted therapeutic than systemic treatments.
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