AI Article Synopsis
- Good results from an in vitro study on JinHuang, a Chinese herbal medicine, prompted an in vivo study to assess safety and efficacy in asymptomatic HIV-infected individuals.
- An open study involving 21 Thai volunteers (12 females, 9 males) took place, with participants taking JinHuang for 6 months, monitored closely for side effects.
- Reported side effects included increased bowel movements (81%) and changes in taste/smell (52%), but no serious adverse events were noted; however, there were no significant changes in viral load or CD4 count, though many participants felt improvements in quality of life.
Article Abstract
Good results of in vitro study of anti-HIV effects of JinHuang, a Chinese herbal medicine led to in vivo study of safety and efficacy among asymptomatic HIV infected individuals. It was a prospective open study of 21 asymptomatic HIV infected Thai volunteers. Twelve and 9 were female and male, respectively, with mean age of 29.24 +/- 3.94 years. JinHuang preparation, 6 capsules and 2 bottles of liquid formula orally three times a day, was given on an outpatient basis initially for 6 months. Regular close monitoring and follow-up were done. The side effects reported included : increased bowel movements (81%), vague taste, and smell of drug after initiation (52%). No serious adverse event related to JinHuang was detected during study. No significant changes in terms of log viral load and CD4 count were observed after 6-months' duration. Most of the patients felt that the quality of life was better in terms of better appetite, good sleep and healthy during study participation, however, these were subjective.
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