AI Article Synopsis
- There is growing interest in developing tests to detect infections, diseases, and environmental stress in fish and other aquatic animals.
- Researchers have isolated and studied the C-reactive protein (CRP) from common carp, which is used in humans as an indicator of inflammation and infection.
- Initial findings indicate that healthy carp have CRP levels comparable to those of healthy humans, and a related protein with potential links to CRP has also been discovered in fish.
Article Abstract
There is increasing economic and ecological interest in the development of assays for the early detection of infection, disease activity and environmental stress in marine and freshwater animals. In humans the serum pentraxin C-reactive protein (CRP) is universally used as a clinical indicator of inflammation and underlying infection. As a first step towards assessing the potential of an immunoassay for CRP in fish, we have isolated and characterised common carp Cyprinus carpio CRP and a highly specific and sensitive anti-carp CRP polyclonal antibody has been raised. The results show levels of CRP in healthy fish similar to those found in healthy humans. A protein of unknown function, which displays the characteristic calcium-dependent phosphate monoester binding exhibited by CRP and some similarity to the known fish pentraxin sequences, has also been identified.
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| http://dx.doi.org/10.1016/s0145-305x(03)00123-x | DOI Listing |
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