AI Article Synopsis
- The study aimed to find predictors of adverse outcomes in pregnant women receiving intravaginal misoprostol for labor induction.
- Conducted with 720 women, results showed tachysystole (frequent contractions) and fetal tachycardia were key predictors of negative outcomes, with odds ratios of 3.7 and 4.8, respectively.
- The model had high specificity (94.2%) but low sensitivity (20.4), suggesting that without these issues, women could expect a safe delivery.
Article Abstract
Objective: To identify predictors of adverse outcome in pregnant women at term receiving 50 microg of intravaginal misoprostol for labor induction.
Study Design: A prospective observational study was conducted of 720 pregnant women at term with an unfavorable cervix and a medical or obstetric indication for labor induction. All patients received 50 microg of intravaginal misoprostol every 4h up to three doses. The primary outcome measure was "adverse outcome" defined as: neonatal death, fetal acidemia and emergent cesarean delivery performed for non-reassuring fetal heart rate tracings. A stepwise logistic regression analysis was used to identify predictors of adverse outcome.
Results: Tachysystole (frequent uterine contractions) (odds ratio (OR), 3.7; 95% confidence interval (CI), 1.2-10.8) and fetal tachycardia (OR, 4.8; 95% CI, 1.4-16.2) were determined as significant predictors of adverse outcome. The specificity of the model was 94.2%, whereas the sensitivity was 20.4%.
Conclusion: In the absence of tachysystole and fetal tachycardia, an uneventful delivery might be expected for women receiving 50 microg of intravaginal misoprostol.
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| http://dx.doi.org/10.1016/s0301-2115(03)00105-2 | DOI Listing |
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