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Snow White's tale in nephrology: the emerging threat of skin-whitening creams on kidney health.
Clin Kidney J
January 2025
Department of Nephrology, Dialysis, Transplantation, Dr C. I. Parhon Hospital, Iasi, Romania.
The timeless tale of Snow White, with its emphasis on fair skin as a beauty ideal, mirrors a contemporary issue in nephrology: the harmful impact of skin-whitening creams on kidney health. Fairness creams have deeply embedded themselves in global society, driven by a pervasive obsession with lighter skin tones as a symbol of beauty. This widespread use reflects deeply rooted cultural beliefs and social norms, despite the significant health risks associated with these products.
View Article and Find Full Text PDFThe Tailpipe's Tale: Traffic-Related Air Pollutants and Ovarian Cancer Risk.
Environ Health Perspect
December 2024
Higher exposure was associated with increased risk of ovarian cancer. Results hinted that age at exposure might matter.
View Article and Find Full Text PDFThe tale of two Ions Na and Cl: unraveling onion plant responses to varying salt treatments.
BMC Plant Biol
October 2024
University of Hohenheim, Institute of Crop Science, Quality of Plant Products 340e, Schloss Westflügel, Stuttgart, 70599, Germany.
Background: Exploring the adaptive responses of onions (Allium cepa L.) to salinity reveals a critical challenge for this salt-sensitive crop. While previous studies have concentrated on the effects of sodium (Na), this research highlights the substantial yet less-explored impact of chloride (Cl) accumulation.
View Article and Find Full Text PDFCombined environmental relevant exposure to perfluorooctanoic acid and zinc sulfate enhances apoptosis through binding with endogenous antioxidants in Daphnia magna.
Food Chem Toxicol
December 2024
Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia; Ocean Pollution and Ecotoxicology (OPEC) Research Group, Universiti Malaysia Terengganu, Malaysia.
Perfluorooctanoic acid (PFOA) is a long-chain legacy congener of the per- and polyfluoroalkyl substances (PFAS) family, notorious as a "forever chemical" owing to its environmental persistence and toxic nature. Essential elements such as zinc (Zn) can cause toxic effects when they change their metal speciation and become bioavailable, such as zinc sulfate (ZnSO). Combined toxicity assessment is a realistic approach and a challenging task to evaluate chemical interactions and associated risks.
View Article and Find Full Text PDFPurpose: We introduce a novel algorithmic approach to design phase I trials for oncology drug combinations.
Methods: Our proposed Toxicity Adaptive Lists Design (TALE) is straightforward to implement, requiring the prespecification of a small number of parameters that define rules governing dose escalation, de-escalation, or reassessment of previously explored dose levels. These rules effectively regulate dose exploration and control the number of toxicities.
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