The INC has been a pioneer in producing cardiac bioprostheses in Mexico. Since the 1970's it has produced and implanted more than 2,500 bioprostheses, first made of duramater and later on, made of cattle pericardium. Nowadays, it is working on the production of a new generation of bioprostheses of cattle pericardium as well as of pigs with or without support; to these, a system to reduce calcification has been added, as a result of research being performed at the Applied Biotechnics Department. In this work we report the first cases operated with one of these new prostheses, the implant of complete grafts to substitute the ascending aorta and pulmonary artery.
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ACS Biomater Sci Eng
January 2025
College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, P.R. China.
Valvular heart disease (VHD) poses a significant threat to human health, and the transcatheter heart valve replacement (THVR) is the best treatment for severe VHD. Currently, the glutaraldehyde cross-linked commercial bioprosthetic heart valves (BHVs) remain the first choice for THVR. However, the cross-linking by glutaraldehyde exhibits several drawbacks, including calcification, inflammatory reactions, and difficult endothelialization, which limits the longevity and applicability of BHVs.
View Article and Find Full Text PDFEur J Cardiothorac Surg
December 2024
Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Objectives: Safety, efficacy and durability are important considerations when selecting a bioprosthesis for aortic valve replacement (AVR). This study assessed 7-year clinical outcomes and haemodynamic performance of the Avalus bioprosthesis.
Methods: Patients indicated for surgical AVR were enrolled in this prospective, nonrandomized trial, conducted across 39 sites globally.
Sovrem Tekhnologii Med
November 2024
PhD, Researcher, Laboratory of New Biomaterials; Research Institute for Complex Issues of Cardiovascular Diseases, 6 Academician L.S. Barbarash Blvd, Kemerovo, 650002, Russia.
Unlabelled: is to assess protective capabilities of the polymer coating made of polyvinyl alcohol to prevent leukocyte adhesion to epoxy-treated bovine pericardium, which is used in production of bioprosthetic heart valves.
Materials And Methods: Fragments of unmodified (control) and modified with polyvinyl alcohol epoxy-treated bovine pericardium were incubated in the dedicated chambers connected to a pulsatile flow system (Ibidi GmbH, Germany). During 48 h incubation was conducted in whole donor plasma containing 310 of mononuclear fraction cells.
ACS Appl Mater Interfaces
November 2024
Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Valve replacement is the most effective means of treating heart valve diseases, and transcatheter heart valve replacement (THVR) is the hottest field at present. However, the durability of the commercial bioprosthetic valves has always been the limiting factor restricting the development of interventional valve technology. The chronic inflammatory reaction, calcification, and difficulty in endothelialization after the implantation of a glutaraldehyde cross-linked porcine aortic valve or bovine pericardium often led to valve degeneration.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:
Tissue deterioration and post-injury infections are the primary cause of skin diseases. Tissue engineering has developed various synthetic and natural polymers to generate bioactive scaffolds that can closely replicate the natural extracellular matrix (ECM). Decellularized tissues have emerged as a potential solution for reconstructing cutaneous lesions due to their ability to preserve the intricate protein structure and provide essential functional domains for cellular differentiation.
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