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One of the main clinical manifestations of infection by the Epstein-Barr virus (EBV) is infectious mononucleosis. In this clinical syndrome, mild hepatitis with a slight elevation of aminotransferases is common. However, cholestasis is rare and usually occurs alongside a more severe, cytolytic hepatitis.

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Emerging Pharmacologic Treatments for Alcohol-Associated Hepatitis: Current Status and Future Landscape.

Clin Liver Dis

November 2024

Medical Service/Gastroenterology, VA Long Beach Healthcare System, 5901 East Seventh Street, Long Beach, CA 90822, USA; Department of Medicine, University of California, Irvine, CA, USA. Electronic address:

Several treatments have shown efficacy in preliminary alcohol-associated hepatitis trials. Interleukin-22 improved Model of End-stage Liver Disease score and aminotransferases in a phase II trial. The endogenous cholesterol derivative, larsucosterol, improved outcomes in a multi-center United States or European phase II trial.

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: Hepatic involvement in measles, particularly among adolescents and adults, has been recognized since 1960. This involvement typically manifests during the eruptive phase of the disease and is primarily characterized by hepatocellular dysfunction, with jaundice being a less common occurrence. Studies have reported hepatic involvement in 80-86% of measles cases among young adults associated with severe forms of the disease with intra-infectious hepatitis.

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Article Synopsis
  • - A 25-year-old patient with a history of unprotected sex developed cholestatic jaundice and severe itching for two months, leading to an examination that revealed intense jaundice and swollen lymph nodes.
  • - Imaging showed edema and lymphadenopathy, while blood tests indicated significant liver enzyme elevation and negative viral serologies, prompting further testing for syphilis, which returned positive.
  • - A liver biopsy confirmed syphilitic hepatitis, resulting in treatment with ceftriaxone, which led to remarkable improvement within 48 hours.
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