Of 166 Bacteroides fragilis isolates, 26.2% of 103 isolates from blood and 20.6% of 63 extraintestinal isolates harbored the fragilysin gene (difference not statistically significant). Clinical characteristics and evolution were comparable in patients with B. fragilis bacteremia with or without this enterotoxin. Fragilysin seems not to be an important virulence factor in B. fragilis disease.
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http://dx.doi.org/10.1128/JCM.41.9.4428-4430.2003 | DOI Listing |
Int J Mol Sci
October 2021
Department of Microbiology and Institute for Rheumatology Research, Hanyang University College of Medicine, Seoul 04763, Korea.
enterotoxin (BFT) produced by enterotoxigenic (ETBF) causes colonic inflammation. BFT initially contacts intestinal epithelial cells (IECs) and affects the intestinal barrier. Although molecular components of the gut epithelial barrier such as metalloproteinase-7 (MMP-7) and syndecan-2 are known to be associated with inflammation, little has been reported about MMP-7 expression and syndecan-2 shedding in response to ETBF infection.
View Article and Find Full Text PDFJ Alzheimers Dis Parkinsonism
May 2021
LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
The human gastrointestinal (GI)-tract microbiome is a rich, complex and dynamic source of microorganisms that possess a staggering diversity and complexity. Importantly there is a significant variability in microbial complexity even amongst healthy individuals-this has made it difficult to link specific microbial abundance patterns with age-related neurological disease. GI-tract commensal microorganisms are generally beneficial to human metabolism and immunity, however enterotoxigenic forms of microbes possess significant potential to secrete what are amongst the most neurotoxic and pro-inflammatory biopolymers known.
View Article and Find Full Text PDFBMC Microbiol
January 2020
Department of Microbiology, Faculty of Medicine, Kuwait University, P. O. Box 24923, 13110, Safat, Kuwait.
Background: Some strains of Bacteroides fragilis species are associated with diarrhea as a result of enterotoxin production (bft or fragilysin). Fragilysin is activated by C11 protease (fpn) and together with C10 protease (bfp) play a significant role in its invasiveness. The objectives of this study were to investigate the proportion of clinical isolates from extra-intestinal sources that are toxin producers and characterize the genes mediating toxin production.
View Article and Find Full Text PDFFront Genet
November 2018
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
ELH-B2 is considered as a potential next-generation probiotic due to its preventive effects on lipopolysaccharides-associated inflammation and intestinal microbiota disorders in mice. To study safety issues associated with ELH-B2, we conducted comprehensive and systematic experiments, including genetic assessments of potential virulence and antimicrobial resistance genes, and an acute toxicity study of both immunocompetent and immunosuppressed mice via cyclophosphamide treatment. The results indicated that this novel strain is non-toxigenic, fragilysin is not expressed, and most of potential virulence genes are correlated with cellular structures such as capsular polysaccharide and polysaccharide utilizations.
View Article and Find Full Text PDFCrit Rev Microbiol
August 2018
a Division of Gastroenterology and Hepatology , Shanghai Jiao-Tong University School of Medicine Renji Hospital, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, State Key Laboratory of Oncogene and Related Gene. Shanghai Institute of Digestive Disease, Shanghai , China.
Metabolism regulation is crucial in colorectal cancer (CRC) and has emerged as a remarkable field currently. The cellular metabolism of glucose, amino acids and lipids in CRC are all reprogrammed. Each of them changes tumour microenvironment, modulates bacterial composition and activity, and eventually promotes CRC development.
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