A 68-year-old asthmatic presented markedly unwell with arthralgia, mononeuritis multiplex, peripheral neuropathy, and eosinophilia. His past medical history included perennial rhinitis, and nasal polyps. Three months prior to admission his prednisolone was stopped and Montelukast was started. The diagnosis of Montelukast-associated Churg-Strauss syndrome was made. The drug was stopped and steroids started with general improvement and reduction of eosinophilia; however, the neurological deficit persisted.
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http://dx.doi.org/10.1093/ageing/afg076 | DOI Listing |
Ann Indian Acad Neurol
October 2015
Department of Pathology, Aster Medcity, Cheranelloor, Kochi, Kerala, India.
Pharmacology
June 2015
School and Division of Allergology and Clinical Immunology, University of Messina, Messina, Italy.
Background: Montelukast, a leucotriene receptor antagonist, binds the cysteinyl leucotriene type 1 receptor. Montelukast is commonly prescribed to asthma patients as add-on therapy to inhaled corticosteroids. Several clinical trials emphasized that montelukast can be considered a safe drug.
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September 2003
Birmingham Heartlands Hospital, Bordsley Green, Birmingham B9 5SS, UK.
A 68-year-old asthmatic presented markedly unwell with arthralgia, mononeuritis multiplex, peripheral neuropathy, and eosinophilia. His past medical history included perennial rhinitis, and nasal polyps. Three months prior to admission his prednisolone was stopped and Montelukast was started.
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