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Metabolic Disturbances Associated with In-Hospital Complication and Mortality in Different Types of Pneumonia.
J Clin Med
December 2024
Department of Pneumology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400332 Cluj-Napoca, Romania.
The mortality rate from community-acquired pneumonia (CAP) or coronavirus disease 19 (COVID-19) is high, especially in hospitalized patients. This study aimed to assess the disturbances of glucose and lipid metabolism with in-hospital complications and short-term outcomes for patients with pneumonia with different etiologies. This observational study comprised 398 patients divided as follows: 155 with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, 129 participants with viral CAP, and 114 with bacterial pneumonia.
View Article and Find Full Text PDFmRNA-LNP vaccines combined with tPA signal sequence elicit strong protective immunity against .
mSphere
December 2024
Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu, China.
is a prominent Gram-negative and encapsulated opportunistic pathogen that causes a multitude of infections such as severe respiratory and healthcare-associated infections. Despite the widespread anti-microbial resistance and the high mortality rate, currently, no clinically vaccine is approved for battling . To date, messenger RNA (mRNA) vaccine is one of the most advancing technologies and are extensively investigated for viral infection, while infrequently applied for prevention of bacterial infections.
View Article and Find Full Text PDFBetaine alleviates methomyl-triggered oxidative stress-mediated cardiopulmonary inflammation in rats through iNOS/Cox2 and Nrf2/HO1/Keap1 signaling pathway.
Toxicol Appl Pharmacol
December 2024
Department of Pathology, Faculty of Veterinary Medicine, Cairo University, P.O. Box 12211, Giza, Egypt.
Article Synopsis
- Methomyl (MET) is a widely used insecticide that causes significant harm to organs like the heart and lungs in humans and animals.
- Betaine (BET), a natural antioxidant, was tested for its protective effects against MET-induced damage in rats, revealing that MET causes oxidative stress and severe tissue damage while BET mitigates these harmful effects.
- The research concludes that BET shields against MET-induced cardiovascular injury and lung inflammation by influencing specific molecular pathways that reduce oxidative stress and inflammation.
Systemic Infection Affecting Multiple Sites After Near-Drowning: A Case Report.
Infect Drug Resist
December 2024
Department of Infectious Diseases, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, 241001, People's Republic of China.
() can cause fungal infections in near-drowning victims, and an increasing number of cases have been reported. However, cases of bone and joint infections caused by are rare. In this case, a 35-year-old otherwise healthy Chinese female presented with aspiration pneumonia and knee arthritis after accidentally falling into sewage and near-drowning and underwent macrogenomic second-generation sequencing of arthrocentesis fluid, which showed .
View Article and Find Full Text PDFAmiodarone-Induced Interstitial Pneumonia: A Cause of Respiratory Failure.
Cureus
November 2024
Internal Medicine, Hospital de Santa Marta, Unidade Local de Saúde São José, Lisbon, PRT.
Amiodarone, a widely used antiarrhythmic medication, is effective for managing various types of cardiac arrhythmias. However, due to its high lipid solubility and long half-life, amiodarone accumulates in various organs, particularly the lungs. Pulmonary toxicity, while rare (1% to 5% incidence), is among the most serious adverse effects of amiodarone, with interstitial pneumonitis (IP) being the most prevalent form of lung toxicity.
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