Treatment of an equimolar mixture of stilbene 7 and cinnamyl alcohol 8 with silver carbonate in acetone-benzene afforded a ca. 2:1:2:1 mixture of the stilbenolignan (+/-)-aiphanol (1) and congeners 2-4 each of which show significant anti-angiogenic and COX-2 inhibitory properties.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/b305106d | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Aiphanol, a multi-targeting stilbenolignan, potently suppresses mouse lymphangiogenesis and lymphatic metastasis.
Acta Pharmacol Sin
January 2023
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
The high incidence of lymphatic metastasis is closely related to poor prognosis and mortality in cancers. Potent inhibitors to prevent pathological lymphangiogenesis and lymphatic spread are urgently needed. The VEGF-C-VEGFR3 pathway plays a vital role in driving lymphangiogenesis and lymph node metastasis.
View Article and Find Full Text PDFIn silico studies on stilbenolignan analogues as SARS-CoV-2 Mpro inhibitors.
Chem Phys Lett
May 2021
Faculty of Health Sciences, University of Mus Alparslan, Mus 49250, Turkey.
COVID-19, a new strain of coronavirus family, was identified at the end of 2019 in China. The COVID-19 virus spread rapidly all over the world. Scientists strive to find virus-specific antivirals for the treatment of COVID-19.
View Article and Find Full Text PDFConvergent synthesis and preliminary biological evaluations of the stilbenolignan (+/-)-aiphanol and various congeners.
Org Biomol Chem
July 2003
Research School of Chemistry, Institute of Advanced Studies, Australian National University, Canberra, ACT 0200, Australia.
Treatment of an equimolar mixture of stilbene 7 and cinnamyl alcohol 8 with silver carbonate in acetone-benzene afforded a ca. 2:1:2:1 mixture of the stilbenolignan (+/-)-aiphanol (1) and congeners 2-4 each of which show significant anti-angiogenic and COX-2 inhibitory properties.
View Article and Find Full Text PDFA novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata.
Org Lett
July 2001
Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Illinois 60612, USA.
[structure: see text] Aiphanol (1), a novel stilbenolignan, along with isorhapontigenin (2), piceatannol (3), and luteolin, were isolated by bioassay-guided fractionation from the seeds of Aiphanes aculeata Willd. (Arecaceae). The structure of compound 1 was elucidated by spectroscopic methods.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!