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How much risk does delirium represent for the development of dementia?: Retrospective cohort study from over 260,000 patients record in a solitary institution.
Front Psychiatry
September 2024
Department of Neuropsychiatry, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
Article Synopsis
- Delirium is a problem that often affects older people in hospitals, and it might increase the chances of them getting dementia later on.
- A study looked at over 261,000 patients in Osaka to see how delirium during hospital stays is related to the development of dementia.
- The results showed that people who experienced delirium had dementia show up much faster compared to those who didn't, highlighting the need to prevent delirium and watch for cognitive decline in these patients.
Donepezil promotes skin flap survival through activation of the HIF-1α/VEGF signalling pathway.
Wound Repair Regen
July 2024
Department of Hand and Plastic Surgery, The Second School of Medicine, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Flaps are mainly used to repair wounds in the clinical setting but can sometimes experience ischaemic necrosis postoperatively. This study investigated whether donepezil, an acetylcholinesterase inhibitor, can enhance the survival rate of flaps. We randomly allocated 36 rats into control, low-dose (3 mg/kg/day), and high-dose (5 mg/kg/day) groups.
View Article and Find Full Text PDFEfficiency of donepezil in elderly patients undergoing orthopaedic surgery due to underlying post-operative cognitive dysfunction: study protocol for a multicentre randomised controlled trial.
Trials
October 2021
Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road, Shanghai, 200127, China.
Background: Post-operative cognitive dysfunction (POCD) is an overarching term used to describe cognitive impairment identified in the preoperative or post-operative period. After surgical operations, older patients are particularly vulnerable to memory disturbances and other types of cognitive impairment. However, the pathogenesis of POCD remains unclear with no confirmed preventable or treatable strategy available.
View Article and Find Full Text PDFPostoperative Administration of the Acetylcholinesterase Inhibitor, Donepezil, Interferes with Bone Healing and Implant Osseointegration in a Rat Model.
Biomolecules
September 2020
Faculty of Dentistry, McGill University, Montreal, QC H3A0C7, Canada.
Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer's disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative administration of donepezil on bone healing remains unknown.
View Article and Find Full Text PDFPharmacological Prevention of Postoperative Delirium: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Evid Based Complement Alternat Med
March 2019
Department of Intensive Care Unit, West China Hospital of Sichuan University, Chengdu, China.
Background: The high prevalence of delirium among postoperative patients has increased morbidity and mortality. The kind of drug that can effectively reduce the incidence of delirium has become the focus of discussion in recent years. However, a consensus in this respect has yet to be reached.
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