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Biosynthetic origin of a branched chain analogue of the lipase inhibitor, lipstatin. | LitMetric

Biosynthetic origin of a branched chain analogue of the lipase inhibitor, lipstatin.

J Med Chem

Lehrstuhl für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Federal Republic of Germany.

Published: September 2003

The lipophilic beta-lactone, lipstatin, inhibits pancreatic lipase and has been shown earlier to be biosynthesized by Claisen condensation of two fatty acid moieties. We present data from incorporation experiments with [U-13C6]leucine showing that a branched chain analogue of lipstatin is biosynthesized from leucine.

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Source
http://dx.doi.org/10.1021/jm030780xDOI Listing

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