Departament de Química Inorgànica, Instituto de Ciencia Molecular, Facultat de Química, Universitat de València, 46100 Burjassot, València, Spain.
Published: September 2003
AI Article Synopsis
Article Abstract
Self-assembly of 1,4-phenylenebis(oxamate) and 4,4'-biphenylenebis(oxamate) ligands and Cu2+ ions gives two new dinuclear copper(II) metallacyclophanes where the two metal centers are connected by double para-substituted aromatic diamide bridges. Despite the relatively large intramolecular Cu-Cu distance of ca. 8 and 12 A for each complex, magnetic susceptibility measurements evidence strong to moderately strong intramolecular antiferromagnetic couplings (-J values of the order of 100 and 10 cm-1, respectively). Density functional theory calculations on these compounds and their homologues with linear oligo-p-phenylenediamide bridges predict a rather slow exponential decay of magnetic coupling with increasing intermetal distance (r values up to 25 A) along this novel series of dicopper metalla-amidocyclophanes.
Age-related atrophy of the human hippocampus and the enthorinal cortex starts accelerating at around age 60. Due to the contributions of these regions to many cognitive functions seamlessly used in everyday life, this can heavily impact the lives of elderly people. The hippocampus is not a unitary structure, and mechanisms of its age-related decline appear to differentially affect its subfields.
It is now understood that brain metastases do not occur randomly but have distinct spatial patterns depending on the origin of the cancer. According to the "seed and soil" hypothesis, the final colonization of metastatic cells is the result of their adaptation to the altered environment. To investigate the most favorable microenvironment for brain metastasis, we analyzed neuroimaging data from 177 patients with breast cancer brain metastasis and 548 patients with lung cancer brain metastasis to create a replicable probabilistic map of metastatic locations.
Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University Wuhan 430071 China
Replacement of a carbonyl group with fluorinated bioisostere (, CF[double bond, length as m-dash]C) has been adopted as a key tactical strategy in drug design and development, which typically improves potency and modulates lipophilicity while maintaining biological activity. Consequently, new -difluoroalkenation reactions have undoubtedly accelerated this shift, and conceptually innovative practices would be of great benefit to medicinal chemists. Here we describe an expeditous protocol for the direct assembly of furan-substituted -difluoroalkenes PFTB-promoted cross-coupling of ene-yne-ketones and difluorocarbene.
Background: Cerebrospinal fluid (CSF) motion and pulsatility has been proposed to play a crucial role in clearing brain waste. Although its driving forces remain debated, increasing evidence suggests that large amplitude vasomotion drives such CSF fluctuations. Recently, a fast blood-oxygen-level-dependent (BOLD) fMRI sequence was used to measure the coupling between CSF fluctuations and low-frequency hemodynamic oscillations in the human cortex.
We have grown (111)- and (001)-oriented NiO thin films on (0001)-Sapphire and (001)-MgO substrates
using pulsed laser deposition (PLD), respectively. DC magnetic susceptibility measurements underline
that the Néel temperatures of the samples are beyond room-temperature. This is further confirmed by
the presence of two-magnon Raman scattering modes in these films in ambient conditions.
