After bioassay-guided fractionation of the extract from Sandoricum koetjape bark, which exhibited significant toxicity to killifish (Oryzias latipes), two ichthyotoxic triterpenoids were isolated and characterized as koetjapic acid and 3-oxo-olean-12-en-29-oic acid. These constituents, along with non-toxic katonic acid, had a remarkable inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA), which is a preliminary in vitro screening method for possible anti-tumor-promoting agents. Of the triterpenoids active in vitro, koetjapic acid appears to be a promising cancer chemopreventive agent, since it significantly delayed tumor promotion in two-stage mouse skin carcinogenesis induced by 7,12-dimethylbenz(a)anthracene and promoted by TPA.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1248/bpb.26.1351 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of and anticancer activities of potassium koetjapate: a solubility improved formulation of koetjapic acid against human colon cancer.
Res Pharm Sci
April 2024
Traditional Medicine Clinical Trial Research Centre, Shahed University, Tehran, Iran.
Background And Purpose: The previous work on koetjapic acid (KA) isolated from showed its efficacy towards colorectal cancer however KA has poor water solubility which poses the biggest hindrance to its efficacy. In the present paper, an attempt was made to study the anti-colon cancer efficacy of KA's potassium salt . potassium koetjapate (KKA) applying and methods.
View Article and Find Full Text PDFCycloartane-type triterpenoids from the leaves of Sandoricum koetjape and their efficacy on α-glucosidase inhibition activity.
J Nat Med
June 2024
Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand.
The preliminary α-glucosidase inhibitory activity of the methanol extract of the leaves of Sandoricum koetjape Merr. exhibited promising results. The leaves was extracted with methanol to obtain the methanol extract that was continuedly partitioned with hexane and ethyl acetate.
View Article and Find Full Text PDFKoetjapic acid: unveiling its potential as a saviour in the realm of biological and medicinal properties, with a focus on anticancer mechanism of action.
Eur J Med Res
February 2024
Victor Babes University of Medicine and Pharmacy of Timisoara, Department of Microbiology, Timisoara, Romania.
Scientists have been compelled to search for alternative treatments due to the increasing prevalence of chemoresistance as well as the agonising and distressing side effects of both chemotherapy and radiation. Plant extracts have been exploited to treat various medical conditions for ages. Considering this fact, the main focus of various recent studies that are being conducted to find new and potent anticancer drugs involves the identification and utilisation of potential therapeutic chemicals present in plant extracts.
View Article and Find Full Text PDFPentacyclic triterpenes from the leaves extract of Sandoricum koetjape.
J Nat Med
September 2022
Organic Chemistry Division, Bandung Institute of Technology, Jalan Ganesha 10, Bandung, 40132, Indonesia.
Three new pentacyclic triterpenes, trivially named sandkoetjapic acids A-C (1-3), have been isolated from the leaves extract of Sandoricum koetjape, along with the known triterpenes 3-oxo-olean-12-en-29-oic (4), bryonolic (5), and bryononic (6) acids. The structures of the new triterpenes were determined mainly by NMR spectroscopic and mass spectroscopic data. The isolation of these pentacyclic triterpenes in the plant's leaves is for the first time.
View Article and Find Full Text PDFThe health benefits of santol fruits and bioactive products isolated from Sandoricum koetjape Merr.: A scoping review.
J Food Biochem
July 2022
OncoWitan, Scientific Consulting Office, Lille, France.
The santol tree (Sandoricum koetjape Merr.) is largely distributed in Southeast Asia. It produces useful timber and edible fruits, consumed fresh, and transformed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!