We studied the effect of ultralow doses of theophylline and morphine, modulators of receptors and intracellular signal systems, on ion permeability of membranes. Theophylline and morphine in ultralow doses blocked the neuronal responses to these agents applied in physiological concentrations. Theophylline in ultralow doses attenuated, but did not completely block neuronal reaction to morphine. These findings suggest that ultralow doses of various substances producing no appreciable physiological changes can activate mechanisms providing optimum response to strong factors.
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