AI Article Synopsis
- Identifying epitopes that can bind to multiple HLA types can improve the creation of epitope-based vaccines.
- A method was used to evaluate over 500 peptides and their interactions with 5 different MHC alleles, revealing a common supermotif for the A2-supertype.
- The study found that HLA-A*6802 has characteristics that place it between the A2 and A3 supertypes, with varying affinities at specific amino acid positions.
- Free models for predicting binding affinities are available online for further research and application.
Article Abstract
Identification of epitopes capable of binding multiple HLA types will significantly rationalise the development of epitope-based vaccines. A quantitative method assessing the contribution of each amino acid at each position was applied to over 500 nonamer peptides binding to 5 MHC alleles--A*0201, A*0202, A*0203, A*0206 and A*6802--which together define the HLA-A2-like supertype. FXIGXI (L)IFV was identified as a supermotif for the A2-supertype based on the contributions of the common preferred amino acids at each of the nine positions. The results indicate that HLA-A*6802 is an intermediate allele standing between A2 and A3 supertypes: at anchor position 2 it is closer to A3 and at anchor position 9 it is nearer to A2. Models are available free on-line at http://www.jenner.ac.uk/MHCPred and can be used for binding affinity prediction.
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| http://dx.doi.org/10.1039/b300707c | DOI Listing |
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