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CIFR (Clone-Integrate-Flip-out-Repeat): a toolset for iterative genome and pathway engineering of Gram-negative bacteria.
Metab Eng
January 2025
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark. Electronic address:
Advanced genome engineering enables precise and customizable modifications of bacterial species, and toolsets that exhibit broad-host compatibility are particularly valued owing to their portability. Tn5 transposon vectors have been widely used to establish random integrations of desired DNA sequences into bacterial genomes. However, the iteration of the procedure remains challenging because of the limited availability and reusability of selection markers.
View Article and Find Full Text PDFCo-existence of two bla and bla on distinct plasmids in a carbapenem-resistant Klebsiella pneumoniae from a tertiary hospital, Tanzania.
J Glob Antimicrob Resist
January 2025
Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Department of Clinical Science, University of Bergen, Bergen, Norway. Electronic address:
Purpose: To understand the mechanisms of carbapenem-resistant Klebsiella pneumoniae (CRKP) from Tanzania and characterize the genomes carrying the carbapenemase genes.
Methods: Clinical CRKP isolates were selected from ongoing antimicrobial-resistant surveillance at Muhimbili National Hospital, Dar es Salaam, Tanzania. Whole-genome sequencing was performed utilizing Illumina and Nanopore platforms.
Emergence and Genetic Characterization of KLUC-3 Extended-Spectrum β-lactamase-producing Escherichia coli ST95 High-Risk Clone Causing Nosocomial Infection in Japan.
J Glob Antimicrob Resist
December 2024
Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Objectives: KLUC β-lactamase is a minor extended-spectrum β-lactamase (ESBL) derived from chromosome-encoded cefotaximase in Kluyvera cryocrescens. This study aimed to characterize the genetic context of KLUC-3-producing Escherichia coli and bla-harboring plasmids and assess nosocomial transmission.
Methods: In a national genomic surveillance conducted in 2019 and 2020, KLUC-3-producing E.
Cross-reactivity of anti-modified protein antibodies in rheumatoid arthritis.
Clin Exp Rheumatol
December 2024
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, and Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Centre for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
This review comprehensively discusses the cross-reactivity of autoantibodies against modified proteins (AMPAs), the hallmark of rheumatoid arthritis (RA). We found that regardless of tissue sources, subtypes, or isotypes of B cells, AMPAs show high cross-reactivity within and across antigens undergoing citrullination, carbamylation, lysine-acetylation or ornithine-acetylation. The cross-reactive patterns of AMPAs display clonal and individual heterogeneity.
View Article and Find Full Text PDFCharacterization of a Novel KPC-2 Variant, KPC-228, Conferring Resistance to Ceftazidime-Avibactam in an ST11-KL64 Hypervirulent Klebsiella pneumoniae.
Int J Antimicrob Agents
December 2024
Department of Clinical Laboratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:
Article Synopsis
- The study investigates the mechanisms of resistance to ceftazidime-avibactam (CZA) in a hypervirulent strain of Klebsiella pneumoniae known as CRE146, which carries the bla gene.
- Researchers isolated twelve carbapenem-resistant Klebsiella pneumoniae strains from a single patient, employing whole genome sequencing and various pathogenicity tests to understand the virulence factors and resistance development.
- Findings revealed that the resistance was linked to drug exposure and involved specific genetic mutations in carbapenemase (KPC-228), with CRE146 showing high resistance to CZA while being more susceptible to other antibiotics like meropenem and imipenem.
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