Potent and specific sialyltransferase inhibitors: imino-linked 5a'-carbadisaccharides.

Org Biomol Chem

Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan.

Published: July 2003

Methyl 5a'-carba-beta-lactoside, imino-linked, has been shown to possess potent and specific inhibitory activity (IC50 = 185 microM) toward rat recombinant alpha2,3-sialyltransferase.

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Source
http://dx.doi.org/10.1039/b304695hDOI Listing

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