[Effect of oxygen deprivation on the development of osteodystrophy caused by the load deficit].

The subject of the study was influence of gas mixture (GGS) with low Po2 on biomechanical properties of femoral and tibial bones in rats after hind-limb unloading. Experiments were performed in two different age groups (three month and six month) rats. It is shown that biomechanical properties of bone tissue in young rats, inhaling atmosferic air, under the influence of 28 days hind-limb unloading deteriorate essentially in comparison with adult rats. The biomechanical indexes of femoral and tibial bones in three month age rats close to control value after periodical inhaling of GGS. In six month age rats normalizing action of low Po2 not so essential. Thus bone tissue of young rats is more sensitive to different pathogenetic action than in adult rats. Such difference may be connected with retard of remodelation of bone tissue in adult rats.