We investigated the parameters driving nelfinavir resistance, along the D30N and L90M evolutionary pathways. The advantage of the D30N mutant was mostly due to its resistance level, while the L90M mutation allowed preservation of infectivity coupled with minimal resistance. Emergence of secondary mutations further increased the selective advantage of viruses harboring D30N.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC224578 | PMC |
| http://dx.doi.org/10.1128/jvi.77.18.10172-10175.2003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Spatio-Temporal Joint Trajectory Planning for Autonomous Vehicles Based on Improved Constrained Iterative LQR.
Sensors (Basel)
January 2025
National Engineering Laboratory for Electric Vehicles, Beijing Institute of Technology, Beijing 100081, China.
With advancements in autonomous driving technology, the coupling of spatial paths and temporal speeds in complex scenarios becomes increasingly significant. Traditional sequential decoupling methods for trajectory planning are no longer sufficient, emphasizing the need for spatio-temporal joint trajectory planning. The Constrained Iterative LQR (CILQR), based on the Iterative LQR (ILQR) method, shows obvious potential but faces challenges in computational efficiency and scenario adaptability.
View Article and Find Full Text PDFEvaluating the Performance Characteristics of Pressure Monitoring Systems.
Sensors (Basel)
January 2025
Skin Sensing Research Group, School of Health Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton SO17 1HE, UK.
Measuring interface pressure is currently used in a variety of settings, e.g., automotive or clinical, to evaluate pressure distribution at support surface interfaces.
View Article and Find Full Text PDFGenetic Risk Profiling Reveals Altered Glycosyltransferase Expression as a Predictor for Patient Outcome in Neuroblastoma.
J Clin Med
January 2025
Research Institute Children's Cancer Center Hamburg, 20251 Hamburg, Germany.
: Neuroblastoma is a highly aggressive pediatric cancer that arises from immature nerve cells and exhibits a broad spectrum of clinical presentations. While low- and intermediate-risk neuroblastomas often have favorable outcomes, high-risk neuroblastomas are associated with poor prognosis and significant treatment challenges. The complex genetic networks driving these high-risk cases remain poorly understood.
View Article and Find Full Text PDFMorphokinetic Analyses of Fishing Cat-Domestic Cat Interspecies Somatic Cell Nuclear Transfer Embryos Through A Time-Lapse System.
Animals (Basel)
January 2025
Endangered Species Conservation via Assisted Reproduction (ESCAR) Lab, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.
A time-lapse live embryo monitoring system provides a powerful approach to recording dynamic developmental events of cultured embryos in detail. By obtaining continuous short-interval images, blastocyst formation can be predicted and embryos can be selected. The objective of this study was to investigate the morphokinetic parameters of fishing cat-domestic cat interspecies somatic cell nuclear transfer (iSCNT) embryos from one-cell to blastocyst stages, and in particular, the cleavage patterns of the first division in iSCNT and IVF embryos, as these play a central role in euploidy.
View Article and Find Full Text PDFAutomated AI-based image analysis for quantification and prediction of interstitial lung disease in systemic sclerosis patients.
Respir Res
January 2025
National Heart and Lung Institute, Imperial College London, London, UK.
Background: Systemic sclerosis (SSc) is a rare connective tissue disease associated with rapidly evolving interstitial lung disease (ILD), driving its mortality. Specific imaging-based biomarkers associated with the evolution of lung disease are needed to help predict and quantify ILD.
Methods: We evaluated the potential of an automated ILD quantification system (icolung) from chest CT scans, to help in quantification and prediction of ILD progression in SSc-ILD.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!