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A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease.
Caspian J Intern Med
January 2023
Department of Parasitology, Faculty of Medicine, Universitas Sebelas Maret, Indonesia.
Background: In the pathogenesis of inflammatory bowel disease (IBD), the advanced glycation end product receptor (RAGE) has been involved. IBD is classified into Chron's disease (CD) and ulcerative colitis (UC). The promoter gene of the RAGE gene was discovered to have had unique polymorphisms that increased its transcriptional activity.
View Article and Find Full Text PDFITGA2 Gene Polymorphism Is Associated with Type 2 Diabetes Mellitus in the Kazakhstan Population.
Medicina (Kaunas)
October 2022
Aitkhozhin Institute of Molecular Biology and Biochemistry, Almaty 050012, Kazakhstan.
Nowadays, every tenth adult in the world suffers from diabetes mellitus (DM). Diabetic retinopathy (DR) is the most common microvascular complication of type 2 DM (T2DM) and a leading cause of acquired blindness in middle-aged individuals in many countries. Previous studies have identified associations of several gene polymorphisms with susceptibility to microvascular complications of DM in various worldwide populations.
View Article and Find Full Text PDFPolymorphisms of the receptor for advanced glycation end products as vasculopathy predictor in sickle cell disease.
Pediatr Res
January 2021
Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Background: The genetic variants of the receptor for advanced glycation end products (RAGE) gene have been associated with vascular disease risk. The objective of this work was to explore the association of three single-nucleotide polymorphisms (SNPs) of RAGE gene (374T/A, 429T/C, and G82S) with vascular complications in SCD.
Methods: The study was conducted on 40 children with SCD and 40 healthy children served as controls.
Receptor for advanced glycation end products gene polymorphisms in cardiac syndrome X.
Biomed Rep
September 2019
Department of Medical Pharmacology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul 34096, Turkey.
Endothelial and microvascular dysfunction serve important roles in the formation and pathogenesis of cardiac syndrome X (CSX). Expression of receptor for advanced glycation end products (RAGE) is suggested to be increased in several conditions, including diabetes, inflammation and vascular diseases. In the present study, gene polymorphisms in patients with CSX and healthy controls were investigated.
View Article and Find Full Text PDFFunctional polymorphisms of the receptor for the advanced glycation end product promoter gene in inflammatory bowel disease: a case-control study.
Clin Exp Med
August 2019
Interdipartimental Center for the Molecular Medicine Research and Cardiology Unit, Istituto di Cura Città di Pavia and University of Pavia, Pavia, Italy.
The receptor for the advanced glycation end products (RAGE) is a multiligand transmembrane receptor involved in chronic inflammation whose specific polymorphisms of the promoter gene were found to increase its transcriptional activity. We investigated the association of both allelic and genotypic -374T/A and -429T/C polymorphisms with inflammatory bowel disease. The STREGA guidelines were applied for planning and reporting.
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