Although evidence for the existence of numerous chlamydia-like microorganisms has been discovered in both environmental samples and clinical specimens, very few have been grown in vitro, and little is known of their pathogenic potential. Of all such organisms, Simkania negevensis is probably the most extensively studied. This review summarizes current knowledge about this intracellular bacterium, focusing especially on human infections.
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Aberrant Bodies: An Alternative Metabolic Homeostasis Allowing Survivability?
Microorganisms
February 2024
Institute of Microbiology, University Hospital of Lausanne, 1005 Lausanne, Switzerland.
The phylum is comprised of obligate intracellular bacteria including human pathogens such as and lesser-known -related bacteria like or . Despite broad differences, these bacteria share a similar development including a persistent state induced using stressors such as immune responses, nutrient starvation, or penicillin introduction. In microbiology, this persistent state is identified by enlarged bacteria, called aberrant bodies, which are unable to divide but are able to survive and resume the developmental cycle upon clearance of the stressor.
View Article and Find Full Text PDFFunctional and structural diversity in deubiquitinases of the Chlamydia-like bacterium Simkania negevensis.
Nat Commun
November 2023
Institute for Genetics, University of Cologne, Cologne, Germany.
Article Synopsis
- Ubiquitination plays a crucial role in cellular processes and helps defend against pathogens, but some bacteria have developed deubiquitinase (DUB) proteins to evade host defenses.
- Legionella pneumophila has a notable number of DUB effectors, including unique K6- and M1-specific enzymes, while the unrelated bacterium Simkania negevensis also encodes multiple DUBs with similar specificities.
- The DUBs from Simkania are diverse and include classes not seen in other bacteria, suggesting independent evolution of M1- and K6-specific enzymes, and the study characterizes the activity and structure of these DUBs.
Development of a duplex q-PCR for the simultaneous detection of Parachlamydia acanthamoebae and Simkania negevensis in environmental and clinical samples.
Anal Biochem
April 2023
Laboratoire de Génie Enzymatique et Microbiologie, Equipe de Biotechnologie des Algues, Ecole Nationale d'Ingénieurs de Sfax, Université de Sfax, 3038, Sfax, Tunisia. Electronic address:
Parachlamydia acanthamoebae and Simkania negevensis, two Chlamydia-like bacteria, have been recently recognized as emerging human respiratory pathogens. The prevalence and frequency of these bacteria in the environment and among atypical pneumonia patients are still underestimated by classical cultures, immunohistochemistry and serology which are non-specific, long and tedious methods. This study aims to develop a new duplex probe-based q-PCR assay for the simultaneous detection and quantification of P.
View Article and Find Full Text PDFFirst evidence for the existence of Simkania negevensis in the genitalia of human females.
Enferm Infecc Microbiol Clin (Engl Ed)
February 2023
Department of Biological Sciences, School of Science, the University of Jordan, Amman, Jordan. Electronic address:
Introduction: Simkania negevensis has been linked to some respiratory and non-respiratory diseases. However, there is still a serious lack of clinical investigations that attempt to determine possible body sites that could be inhabited by this microorganism and evaluate its true pathogenic capacity. The goal of this study was to examine the potential presence of Simkania and its prevalence in the genital tract of human adult females.
View Article and Find Full Text PDFFirst evidence for the existence of Simkania negevensis in the genitalia of human females.
Enferm Infecc Microbiol Clin (Engl Ed)
July 2021
Department of Biological Sciences, School of Science, the University of Jordan, Amman, Jordan. Electronic address:
Introduction: Simkania negevensis has been linked to some respiratory and non-respiratory diseases. However, there is still a serious lack of clinical investigations that attempt to determine possible body sites that could be inhabited by this microorganism and evaluate its true pathogenic capacity. The goal of this study was to examine the potential presence of Simkania and its prevalence in the genital tract of human adult females.
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