The authors report six cases of giant condyloma accuminatum and evaluate the use of mesh-skin grafts in covering the skin defect after radical local excision of perianal giant condyloma acuminatum. Medical records of six patients suffering from the giant condylomata acuminata and treated surgically at the Department of Surgery, Clinical Hospital Center Zagreb, were examined. Use of mesh-skin grafts in covering the skin defect after radical local excision of GCA was compared to other methods of treating the skin defect after radical excision of perianal lesions such as secondary wound healing. Four patients were treated by radical local excision and two patients were treated by abdominoperineal resection. There were partial graft failures (satisfactory result) in all patients and complete healing took about 3 to 4 weeks from time of grafting. A mesh-skin graft was used to cover the skin defect. There were no recurrences, wound infections, wound bleeding, hypertrophic scars, or mesh-like skin appearance of the recipient site. Therefore a good cosmetic and functional result was achieved. Use of mesh-grafts in covering the wounds after radical excision of anorectal giant condylomata acuminata compares favorably to healing by secondary intention in terms of wound healing time, and gives good functional and cosmetic results.
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Int J Biol Macromol
January 2025
College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China. Electronic address:
Bacterial infections impede skin wound healing, and antibacterial hydrogels have garnered significant attention in the field of wound care due to their combined therapeutic effects. In this study, an intelligent, responsive AC-Gel@Cur-Au hydrogel was developed using temperature-sensitive agarose and pH-responsive chitosan as the structural framework, infused with Gel@Cur and AuNR. The AC-Gel@Cur-Au hydrogels demonstrated excellent mechanical properties, swelling capacity, tissue adhesion, and biodegradability.
View Article and Find Full Text PDFJ Am Acad Orthop Surg Glob Res Rev
January 2025
From the Department of Orthopaedic Surgery, Foot and Ankle Research and Innovation Laboratory (FARIL), Massachusetts General Hospital, Harvard Medical School, Boston, MA (Flaherty, Ghandour, Mirochnik, Lucaciu, Nassour, Kwon, and Ashkani-Esfahani); the Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA (Kwon, Harris, and Ashkani-Esfahani); and the Department of Orthopaedic Surgery, Massachusetts General Hospital, Division Foot and Ankle, Harvard Medical School, Boston, MA (Kwon and Ashkani-Esfahani).
Background: Approximately 25% of children in the United States experience child abuse or neglect, 18% of whom are physically abused. Physicians are often in a position to differentiate accidental trauma from physical child abuse. Therefore, the aim of this study was to review recent literature for risk factors associated with physical child abuse.
View Article and Find Full Text PDFPlast Reconstr Surg Glob Open
January 2025
Division of Plastic and Reconstructive Surgery, University of Texas Health Science Center San Antonio, San Antonio, TX.
When squamous cell carcinoma necessitates mandibular resection, the resultant defect can be complex. An osteocutaneous fibula free flap is an effective reconstruction option, typically supplied by the peroneal artery for both the fibula and skin flap. In this case report, an anatomical variation was found: the skin paddle was supplied by soleus musculocutaneous perforators of the posterior tibial artery, whereas the fibula was supplied by the peroneal artery.
View Article and Find Full Text PDFTransl Pediatr
December 2024
Department of Pediatric Intensive Care Unit, National Regional Medical Center, Guizhou Branch of Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Guizhou Provincial People's Hospital, Guiyang, China.
Background: Metabolic cardiomyopathy is characterized by structural and functional changes to the heart and interstitial fibrosis without coronary artery disease or hypertension. Inborn metabolic defects are a common cause of cardiomyopathy in children. There are more than 40 kinds of inborn metabolic defects that cause cardiomyopathy.
View Article and Find Full Text PDFArthroplast Today
December 2024
Hospital Pavia Arecibo, Arecibo Orthopedic Institute, Arecibo, PR, USA.
Synovial fistula of the knee occurs when a defect in the joint capsule creates a connection between skin, bursa, and a near tissue, manifesting as an opening with continuous draining fluid or a cyst. This is a case of an 80-year-old male who developed a synovial fistula with cystic presentation 6 years after the primary total knee arthroplasty. Management included a total knee arthroplasty revision surgery with intraoperative identification of the fistula with methylene blue, and using a gelatin-thrombin matrix for closure.
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