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cfDNA hydroxymethylcytosine profiling for detection metastasis and recurrence of Esophageal Squamous Cell Carcinoma.
World J Surg Oncol
March 2025
Section of Esophageal and Mediastinal Oncology, Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: A blood-based approach to monitor metastasis and recurrence of esophageal squamous cell carcinoma (ESCC) remains undeveloped. This study aimed to establish a dependable model utilizing cfDNA 5-hydroxymethylcytosines (5hmC) signatures to detect these conditions in ESCC.
Methods: The 5hmC-Seal technique was employed to generate comprehensive 5hmC profiles from the plasma cell-free DNA (cfDNA) of 122 ESCC patients, classified into 72 with metastasis, 50 without metastasis, 30 with recurrence, and 92 without recurrence.
"I feel like my job is to give patients hope" - perspectives of Community Health Workers and employers in Iowa: a mixed methods study.
BMC Health Serv Res
March 2025
University of Iowa Prevention Research Center for Rural Health, Iowa City, IA, USA.
Introduction: Community Health Workers (CHWs) play a crucial role in extending health services, particularly for people who are medically underserved. Despite efforts to expand CHW programs nationally and in Iowa, challenges persist in defining their roles and responsibilities. Few studies have considered the perspectives of both CHWs and CHW employers simultaneously.
View Article and Find Full Text PDFAssociation of LHCGR rs2293275 genotype with ovarian aging in Chinese women: a multicenter population-based study.
Reprod Biol Endocrinol
March 2025
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Objective: To evaluate the association between the LHCGR rs2293275 (N312S) genotype and ovarian aging phenotypes in Han Chinese women, focusing on diminished ovarian reserve (DOR) and primary ovarian insufficiency (POI).
Study Design: This multicenter population-based study included 1,240 women aged 18-40 years diagnosed with DOR (n = 711) or POI (n = 529), alongside 72,846 ethnically and regionally matched controls from the Han Chinese Genomes Database (PGG.Han).
Publicly Available Imaging Datasets for Age-related Macular Degeneration: Evaluation according to the Findable, Accessible, Interoperable, Reusable (FAIR) Principles.
Exp Eye Res
March 2025
Department of Ophthalmology, University of Washington, Seattle, Washington; Roger and Angie Karalis Johnson Retina Center, Seattle, Washington. Electronic address:
Age-related macular degeneration (AMD), a leading cause of vision loss among older adults, affecting more than 200 million people worldwide. With no cure currently available and a rapidly increasing prevalence, emerging approaches such as artificial intelligence (AI) and machine learning (ML) hold promise for advancing the study of AMD. The effective utilization of AI and ML in AMD research is highly dependent on access to high-quality and reusable clinical data.
View Article and Find Full Text PDFToxicity of resin-matrix composites in a dental clinical setting.
Odontology
March 2025
Faculty of Dental Medicine, Universidade Católica Portuguesa, Estrada da Circunvalação, 3504-505, Viseu, Portugal.
The aim of this study was to perform a systematic review to comprehensively explore the factors contributing to the resin-matrix composites' toxicity in patients. A systematic review was performed according to the PRISMA guidelines. The bibliographic review was performed in the following databases: PubMed, Cochrane Central and Web of Science.
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