In order to obtain the aluminum resonant double lines, Al I 396.15 nm and Al I 394.40 nm, we have recorded the time-resolved spectra of the plasma induced by Nd:YAG laser ablating metal aluminum in Ar, under the Ar ambient pressure 10 kPa, at 0.1 mm in front of the target, with laser pulse energy 145 mJ/pulse. Relative intensities of the double lines were acquired by integrating the area under the double lines, respectively. According to the ratio of the intensities of the double lines, the ratio of transition probability of the double lines was deduced, and contrasted with the theoretical value. As the result, we found they tally with each other exactly. Limited to our experimental condition, we could only estimate approximately the ratio of transition probability of the double lines. Further experiments were needed for precise measurements of respective transition probability of the double lines.
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Int J Biol Macromol
January 2025
School of Biological and Food Engineering, Guangxi Science & Technology Normal University, Laibin, Guangxi 546199, China. Electronic address:
Targeting DNA repair mechanisms, particularly PARP-1 inhibition, has emerged as a promising strategy for developing anticancer therapies. we designed and synthesized two 2-thiazolecarboxaldehyde thiosemicarbazone palladium(II) complexes (C1 and C2), and evaluated their anti-cancer activities. These Pd(II) complexes exhibited potent PARP-1 enzyme inhibition and demonstrated considerable antiproliferative activity against various cancer cell lines.
View Article and Find Full Text PDFCommun Biol
January 2025
Protein Interactome Laboratory for Structural and Functional Biology, Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai, India.
Why cancer cells disproportionately accumulate polyubiquitinated proteotoxic proteins despite high proteasomal activity is an outstanding question. While mis-regulated ubiquitination is a contributing factor, here we show that a structurally-perturbed and sub-optimally functioning proteasome is at the core of altered proteostasis in tumors. By integrating the gene coexpression signatures of proteasomal subunits in breast cancer (BrCa) patient tissues with the atomistic details of 26S holocomplex, we find that the transcriptional deregulation induced-stoichiometric imbalances perpetuate with disease severity.
View Article and Find Full Text PDFClin Imaging
January 2025
Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States of America.
Purpose: To evaluate henna as a durable skin marker on various skin tones for sonographic targeting and to identify the shortest duration of henna application needed for practical clinical workflow.
Materials And Methods: Prospective study applying seven henna lines through ultrasound (US) gel on the forearms of 15 healthy participants equally represented across the validated six-color bar tool. Color bar categories 1-2, 3-4, and 5-6 were designated low, moderate, and high-melanin groups, respectively.
Knee Surg Sports Traumatol Arthrosc
January 2025
Department of Orthopedics and Trauma, Medical University of Graz, Graz, Austria.
Purpose: >The aim of this multicenter study was to analyze the potential impact of patient demographics and cementation technique towards the development of radiolucent lines (RLLs) in primary total knee arthroplasty (TKA). It was hypothesized that cementation techniques, including higher cement volume, double-layer cementation technique and hardening in full extension, reduce RLL incidence by improving stability, whereas demographic factors such as age, BMI and smoking may increase RLL risk by affecting bone quality and mechanical loading.
Methods: Altogether, 776 patients (median age: 70.
Nurs Crit Care
January 2025
Department of Nursing, Faculty of Health Science, Gaziantep University, Gaziantep, Turkey.
Background: Turkey has been exposed to many devastating earthquakes in recent years. Considering that nurses are on the front lines of responding to disasters, they need to be prepared at all times. In the literature review, it was seen that despite the roles of intensive care nurses in disasters, their experiences in caring for earthquake victims have not been adequately researched.
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