In CTX-M-9 extended-spectrum beta-lactamases (ESBLs), an S130G mutation induced a 40- to 650-fold increase in 50% inhibitory concentrations but decreased hydrolytic activity against cefotaxime. A D240K mutation did not modify enzymatic efficiency against ceftazidime. Residue K240 could interact with Q270 and therefore not with ceftazidime, in contrast with what was observed with certain TEM/SHV-type ESBLs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC182627 | PMC |
| http://dx.doi.org/10.1128/AAC.47.9.2958-2961.2003 | DOI Listing |
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