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IgG4-related disease for the hematologist.
Hematology Am Soc Hematol Educ Program
December 2024
Division of Hematology, University of British Columbia, Vancouver, British Columbia, Canada; and Division of Hematology, Dalhousie University, Halifax, Nova Scotia, Canada.
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated disease with many important manifestations in hematopoietic and lymphoid tissue. IgG4 is the least naturally abundant IgG subclass, and the hallmark feature of IgG4-RD is markedly increased IgG4-positive plasma cells (with an IgG4 to IgG ratio >40%) in affected tissue, along with elevated polyclonal serum IgG and IgG4 in most patients. Histological diagnosis is essential, and other key features include storiform fibrosis, lymphoplasmacytic infiltrate, tissue eosinophilia, and obliterative phlebitis.
View Article and Find Full Text PDFPerinephric myxoid pseudotumor of fat: A series of 13 cases and literature review.
Hum Pathol
November 2024
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA. Electronic address:
Perinephric myxoid pseudotumor of fat (PMPF) is a recently described and rare retroperitoneal mass-forming lesion whose clinical significance chiefly involves mimicry of a variety of soft tissue tumors. For unknown reasons, it commonly occurs in male patients with underlying non-neoplastic renal diseases and/or type 2 diabetes (DMT2). A total of 55 cases have been reported in the literature.
View Article and Find Full Text PDFBenign Tumors and Tumor-Like Conditions of Ampulla and Small Intestine: The PathologyOutlines.com Review.
Int J Surg Pathol
October 2024
PathologyOutlines.com Owner and Founder.
Article Synopsis
- The small intestine and ampulla can develop various benign tumors and tumor-like diseases that may resemble cancer, highlighting the need for pathologists to have a comprehensive understanding of these conditions.
- Key examples of these benign issues include Brunner gland lesions, different types of polyps, and various mesenchymal proliferations like inflammatory fibroid polyps and leiomyomas.
- The review aims to clarify the histopathological features of these benign conditions to aid pathologists in making accurate diagnoses and differentiating them from malignant tumors.
Primary paraduodenal tuberculosis in its pseudotumoral form: A case report and review of the literature.
Radiol Case Rep
November 2024
Department of Radiology, Mohammed V Military Hospital, Mohammed V University, Rabat, Morocco.
Article Synopsis
- Abdominal tuberculosis can be hard to diagnose because its symptoms are vague, often causing delays in treatment.
- A 48-year-old man was incorrectly diagnosed with a gastrointestinal tumor but actually had retroperitoneal pseudo-tumoral tuberculosis, leading to unnecessary surgery.
- Following proper diagnosis through pathology, the patient successfully received 6 months of antitubercular treatment, emphasizing the need for early biopsies to avoid such misdiagnoses.
Article Synopsis
- A 49-year-old man visited the emergency department with symptoms including weight loss, abdominal pain, and elevated inflammatory markers, leading to the discovery of a large liver tumor and swollen bile ducts.
- The tumor raised concerns for intrahepatic cholangiocarcinoma, prompting surgical procedures including segmental hepatectomy and lymphadenectomy.
- Post-surgery analysis revealed the tumor was an IgG4-associated disease, and the patient showed positive recovery without any recurrence of symptoms.
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