AI Article Synopsis
- The study focused on analyzing urine samples for diazolo- and triazolobenzodiazepines using beta-glucuronidase hydrolysis and methylene chloride extraction.
- The resulting extracts were modified to form methyl derivatives, which were then analyzed through gas chromatography/mass spectrometry (GC/MS).
- The test showed good precision and linear calibration curves, with operational limits of quantitation between 13-25 ng/mL.
Article Abstract
Urine samples containing diazolo- and triazolobenzodiazepines and metabolites were hydrolyzed with beta-glucuronidase and extracted with methylene chloride. The extracts were treated with methyl iodide, methylene chloride, and tetrahexylammonium hydrogen sulfate in basic solution to form the methyl derivatives of the drugs and metabolites. GC/MS analysis resulted in the following test characteristics: day-to-day precision at 360 ng/mL (120 ng/mL for the triazolobenzodiazepine metabolites) was 2.4 to 5.5% CV; calibration curves were linear to 6000 ng/mL (1000 ng/mL for the triazolobenzodiazepine metabolites), and operational limits of quantitation were in the range 13-25 ng/mL.
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| http://dx.doi.org/10.1093/jat/16.6.363 | DOI Listing |
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