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In the Rutaceae family is the biggest among all fruits, tradtionally used for several purposes due to its diverse ethnomedicinal, phytochemical, and pharmacological activities. Different portions of this plant have been used as sedatives and anti-inflammatory medications, as well as to treat coughs, fevers, asthma, diarrhea, ulcers, and diabetes. There is a scientific potential for the methanolic seed extract to contain bioactive compounds, similar to those found in other parts of the plant.
View Article and Find Full Text PDFspores maintain gut homeostasis in murine ulcerative colitis via modulating microbiota, apoptosis, and the TXNIP/NLRP3 inflammasome cascade.
Toxicol Rep
June 2025
Pharmcology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Ulcerative colitis (UC), a persistent immune-mediated disorder lacking effective treatment, is distinguished by gut microbiota dysbiosis, abnormal activation of the NLRP3 inflammasome pathway, and apoptosis. Despite growing attention to these factors, understanding their significance in UC pathogenesis remains a challenge. The present study explores the potential therapeutic impact of (Bc) spores in a murine UC model induced by drinking 4 % (w/v) dextran sulfate sodium (DSS) in C57BL/6 mice.
View Article and Find Full Text PDFImmune checkpoint inhibitor-associated gastrointestinal adverse events in patients with colorectal cancer.
Ann Gastroenterol
December 2024
Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA (Saltenat Moghaddam Adames, Malek Shatila, Yinghong Wang, Anusha Thomas).
Background: Immune checkpoint inhibitors (ICI) target microsatellite instability-high (MSI-H) tumors with success. The incidence and characteristics of ICI-related colitis (IMC) in patients with MSI-H colorectal cancers (CRC) are unclear.
Methods: We performed a retrospective analysis of adult patients with CRC who received ICI between June 1, 2014, and December 31, 2022, including data on IMC observed up to 3 months after the last dose of ICI.
Transcriptomic Insights into the Molecular Mechanisms of Indole Analogues from the Extract and Their Therapeutic Effects on Ulcerative Colitis.
Animals (Basel)
December 2024
Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu 610065, China.
Ulcerative colitis (UC) is an inflammatory disease of the intestinal mucosa, and its incidence is steadily increasing worldwide. As a traditional Chinese medicinal insect, has been broadly utilized in clinical practice to treat wound healing. The tryptophan (Trp), tryptamine (Try), and 1,2,3,4-tetrahydrogen-β-carboline-3-carboxylic acid (Thcc) identified from concentrated ethanol-extract liquid (PACEL) exhibit significant cell proliferation-promoting and anti-inflammatory effects in the treatment of UC, but the mechanism involved remains obscure.
View Article and Find Full Text PDFChronic active Epstein‒Barr virus colitis, a rare cause of recurrent diarrhea in an immunocompetent female: a case report.
BMC Infect Dis
January 2025
Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, China.
Background: Chronic active Epstein-Barr virus (CAEBV) colitis is a rare disease with clinical and endoscopic manifestations very similar to those of inflammatory bowel disease (IBD). In clinical practice, it is easy to be misdiagnosed and mistreated, leading to poor clinical outcomes.
Case Presentation: We report a case of a 56-year-old Chinese woman who presented with 6 years of intermittent severe diarrhea, fever, and abdominal pain.
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