AI Article Synopsis
- Researchers created macrocyclic peptidomimetics with both peptide and peptoid structures.
- These compounds demonstrated antibiotic effectiveness against both gram-positive and gram-negative bacteria while showing low toxicity to human red blood cells.
- One of the compounds was found to adopt a stable beta-hairpin shape when analyzed using NMR in water.
Article Abstract
Macrocyclic peptidomimetics having a mixed peptide-peptoid backbone have been synthesized and shown to possess antibiotic activity against gram-positive and -negative bacteria with a low hemolytic activity against human erythrocytes; one is shown to adopt a regular beta-hairpin conformation by NMR in aqueous solution.
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| http://dx.doi.org/10.1039/b304310j | DOI Listing |
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