Arteriolar and venular reactions and capillary blood flow in response to exogenous nitric oxide were studied on the hamster buccal sac capillaries. Heterogeneous reactions of capillaries were observed after exposure to NO; vasoconstriction and vasodilatation were observed equally often, the reactions of arterioles and venules being specific. The microcirculation index changed negligibly, the fluxmotion index increased due to increasing effects of active mechanisms, and the vascular tone decreased.

Download full-text PDF

Source

Publication Analysis

Top Keywords

hamster buccal
8
buccal sac
8
exogenous nitric
8
[microcirculatory bed
4
bed hamster
4
sac conditions
4
conditions exposure
4
exposure exogenous
4
nitric oxide]
4
oxide] arteriolar
4

Similar Publications

Differences in near-infrared fluorescence imaging and histological analysis of cheek mucosa in golden hamsters with different pathological states.

Hua Xi Kou Qiang Yi Xue Za Zhi

December 2024

Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing 210008, China.

Objectives: To explore and analyze the feasibility of using indocyanine green (ICG) near-infrared fluorescence (NIF) imaging technology for the early diagnosis of oral potential malignant disorders and oral squamous cell carcinoma.

Methods: 7,12-Dimethylbenz[a]anthracene in acetone solution was used to induce various pathological models of buccal mucosal lesions (mild/moderate dysplasia, severe dysplasia, squamous cell carcinoma) in golden hamster. ICG-NIF was conducted for the quantitative analysis of the fluorescence signal of lesion tissue, and evaluation of the diagnostic and discriminative capabilities of the ICG-NIF technology for mucosal lesions in various pathological states.

View Article and Find Full Text PDF

Background: The mechanisms of inflammation and carcinogenesis are significantly influenced by nitric oxide (NO). Three different kinds of nitric oxide synthase (NOS) have been previously found: neuronal NOS, inducible nitric oxide synthase (iNOS), and endothelial NOS.

Objectives: This study looked into the properties of iNOS in hamster buccal pouch carcinogenesis caused by 7,12-dimethylbenz[a]anthracene (DMBA).

View Article and Find Full Text PDF

Yohimbine is a potent bioactive indole alkaloid, isolated from a variety of biological sources and has long been used as a natural stimulant and aphrodisiac, particularly to treat erectile dysfunction. However, some literature also points toward its anticancer effect in different experimental models. The current study aimed to address a clinical concern on the therapeutic utilization of yohimbine as a repurposed drug.

View Article and Find Full Text PDF
Article Synopsis
  • The study assesses the effectiveness of PLGA-loaded Nedaplatin (PLGA-NDP) in treating oral cancer induced by DMBA in a hamster model, where DMBA exposure led to the development of oral squamous cell carcinoma (OSCC).
  • PLGA-NDP was administered both before and after carcinogen exposure, showing promising results in reducing tumor formation and altering key molecular proteins associated with cancer progression.
  • Findings revealed that PLGA-NDP inhibits Notch signaling, which is linked to apoptosis, suggesting that targeting this pathway could provide a new strategy for treating OSCC.
View Article and Find Full Text PDF

Background: Betel quid and its major ingredient, areca nut, are recognized by IARC as major risk factors in oral cancer development. Areca nut extract (ANE) exposure has been linked to OPMD progression and malignant transformation to OSCC. However, the detailed mechanism through which ANE acts on other cell types in the oral microenvironment to promote oral carcinogenesis remains elusive.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!