Arteriolar and venular reactions and capillary blood flow in response to exogenous nitric oxide were studied on the hamster buccal sac capillaries. Heterogeneous reactions of capillaries were observed after exposure to NO; vasoconstriction and vasodilatation were observed equally often, the reactions of arterioles and venules being specific. The microcirculation index changed negligibly, the fluxmotion index increased due to increasing effects of active mechanisms, and the vascular tone decreased.
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Hua Xi Kou Qiang Yi Xue Za Zhi
December 2024
Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing 210008, China.
Objectives: To explore and analyze the feasibility of using indocyanine green (ICG) near-infrared fluorescence (NIF) imaging technology for the early diagnosis of oral potential malignant disorders and oral squamous cell carcinoma.
Methods: 7,12-Dimethylbenz[a]anthracene in acetone solution was used to induce various pathological models of buccal mucosal lesions (mild/moderate dysplasia, severe dysplasia, squamous cell carcinoma) in golden hamster. ICG-NIF was conducted for the quantitative analysis of the fluorescence signal of lesion tissue, and evaluation of the diagnostic and discriminative capabilities of the ICG-NIF technology for mucosal lesions in various pathological states.
Cureus
October 2024
Department of General Medicine, Al Azhar Medical College Hospitals and Research Institute, Thodupuzha, IND.
Background: The mechanisms of inflammation and carcinogenesis are significantly influenced by nitric oxide (NO). Three different kinds of nitric oxide synthase (NOS) have been previously found: neuronal NOS, inducible nitric oxide synthase (iNOS), and endothelial NOS.
Objectives: This study looked into the properties of iNOS in hamster buccal pouch carcinogenesis caused by 7,12-dimethylbenz[a]anthracene (DMBA).
Cell Biochem Funct
September 2024
Department of Biochemistry and Biotechnology, Centre for Research and Development, PRIST University, Thanjavur, Tamil Nadu, India.
Yohimbine is a potent bioactive indole alkaloid, isolated from a variety of biological sources and has long been used as a natural stimulant and aphrodisiac, particularly to treat erectile dysfunction. However, some literature also points toward its anticancer effect in different experimental models. The current study aimed to address a clinical concern on the therapeutic utilization of yohimbine as a repurposed drug.
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September 2024
Department of Biochemistry and Biotechnology, Annamalai University, Chidambaram, Tamil Nadu, India.
J Exp Clin Cancer Res
August 2024
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan.
Background: Betel quid and its major ingredient, areca nut, are recognized by IARC as major risk factors in oral cancer development. Areca nut extract (ANE) exposure has been linked to OPMD progression and malignant transformation to OSCC. However, the detailed mechanism through which ANE acts on other cell types in the oral microenvironment to promote oral carcinogenesis remains elusive.
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