AI Article Synopsis
- A study with 25 patients who experienced their first acute Q-wave anterior myocardial infarction looked at the effects of combining enoximone and dobutamine to evaluate heart muscle viability.
- Using low-dose dobutamine echocardiography and enoximone very low-dose echocardiography, researchers recorded significant improvements in wall-motion scores of severely affected heart areas during drug peak effects and continued monitoring after 4 months post-surgery.
- A strong correlation was found between initial drug effects and long-term heart function in patients, suggesting that enoximone very low-dose echocardiography is a valuable tool for assessing heart muscle viability, especially in difficult cases.
Article Abstract
Relying on the synergistic action on contractility of enoximone and dobutamine when concomitantly infused, 25 patients with their first acute Q-wave anterior myocardial infarctions underwent conventional low-dose dobutamine echocardiography (LDE) and enoximone very-LDE to assess myocardial viability in severely dysfunctioning areas. Images were recorded at peak of pharmacodynamic effect of drugs and 4 months after revascularization. At peak-dose stage of LDE and enoximone very-LDE the regional infarct zone wall-motion score significantly decreased from the basal value of 25.6 +/- 2.9 to 16 +/- 6.0 (P <.001) and to 14.5 +/- 5.2 (P <.001), respectively. A high correlation was found by comparing the wall-motion score of each patient calculated at peak effect of combined drug administration with follow-up values (r(s) = 0.9). Enoximone very-LDE has proven to be a new test useful to evaluate viability in asynergic segments especially when the results of conventional tests are questionable.
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| http://dx.doi.org/10.1016/S0894-7317(03)00478-4 | DOI Listing |
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