Haseman and Elston (H-E) proposed a regression-based robust test of linkage between a marker and an autosomal quantitative trait locus, using the squared sib pair trait difference as a dependent variable and the proportion of alleles shared identical by descent by the sib pair as an independent variable. Several authors have proposed improvement of the original H-E's seminal work by using an optimal linear combination of squared sum and squared difference as the dependent variable. In this paper, we extend Haseman and Elston's sib pair method to an X-linked locus. We give a general formulation of the complete regression model and details of the regression coefficients in terms of variance components. Simulation results are presented to describe the power of this technique for a theoretical best case scenario.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000072314 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study.
Front Psychol
December 2024
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Background: Consistent findings indicate that Theory of Mind (ToM) is impaired in schizophrenia (SZ). To investigate whether such deficits are trait- or state-dependent, we investigated if ToM is modified by clinical liability markers (such as basic symptoms and psychotic-like experiences), focusing on the analysis of unaffected siblings of individuals diagnosed with SZ.
Methods: The study included a total of 65 participants: 38 patients diagnosed with a schizophrenia-spectrum disorder and 27 healthy siblings.
Parental Reconstruction from a Half-Sib Population of Stoneless Jujube Mill. Based on Individual Specific SNP Markers Using Multiplex PCR.
Plants (Basel)
November 2024
State Key Laboratory of Tree Genetics and Breeding, National Engineering Research Center of Tree Breeding and Ecological Restoration, Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China.
The selection of unique and individual-specific SNPs is important as compared with universal SNPs for individual identification. Therefore, the main significance of this research is the selection of specific SNPs in male parent and the identification of offspring with these specific SNPs in their genome by multiplex PCR, which is utilized for genotyping of 332 half-sib plants of .This cost-effective method makes as much as possible to utilize the same amount of each pair of various targeted loci primers.
View Article and Find Full Text PDFPairing interacting protein sequences using masked language modeling.
Proc Natl Acad Sci U S A
July 2024
Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
Predicting which proteins interact together from amino acid sequences is an important task. We develop a method to pair interacting protein sequences which leverages the power of protein language models trained on multiple sequence alignments (MSAs), such as MSA Transformer and the EvoFormer module of AlphaFold. We formulate the problem of pairing interacting partners among the paralogs of two protein families in a differentiable way.
View Article and Find Full Text PDFThe Garden of Forking Paths: Reinterpreting Haseman-Elston Regression for a Genotype-by-Environment Model.
Behav Genet
July 2024
Center for Reproductive Medicine, Department of Genetic and Genomic Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Article Synopsis
- The study reinterprets the classic Haseman-Elston regression (HE-reg) to show that it can detect gene-environment interactions (GxE) under specific conditions.
- It highlights the discrepancies between linkage and association results when GxE is present, particularly when the environmental factors are unknown.
- The authors propose two new statistical tests (Symmetry Test I & II) to analyze GxE using summary statistics, emphasizing the need for more sibling pairs to enhance the statistical power of these tests.
Multitrait genetic parameter estimates in a Tenebrio molitor reference population: high potential for breeding gains.
Animal
June 2024
Ÿnsect, R&D Biotech Innovations, Evry 91000, France.
To address multiple issues impacting the climate imbalance, insects, and in particular Tenebrio molitor, represent now a promising alternative for producing high-quality protein products with low environmental impact. As with any new species farmed on an industrial scale, insect breeding production must be improved through the accumulation of knowledge on rearing techniques and genetic management. Little information on the inheritance of agronomically interesting traits, dedicated to Tenebrio molitor, is available.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!