The persistence of senescence.

Sci Aging Knowledge Environ

Department of Medicine, Lineberger Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

Published: August 2003

AI Article Synopsis

  • Senescence acts as a strong defense against cancer, making it difficult for potential tumor cells to become malignant.
  • The article reviews two recent studies that explore how long senescence lasts and its impact on cancer development.
  • Insights from these studies are relevant to researchers in both aging and cancer fields, highlighting the interconnectedness of these areas.

Article Abstract

Senescence is a potent anticancer mechanism, representing a barrier that most, if not all, would-be tumor cells must traverse on their path to malignant transformation. In this Perspective, I discuss two recent publications (1, 2) that deal with the durability of senescence. These findings are of interest not only to those who study aging, but to those who study cancer as well.

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Source
http://dx.doi.org/10.1126/sageke.2003.33.pe24DOI Listing

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