Senescence is a potent anticancer mechanism, representing a barrier that most, if not all, would-be tumor cells must traverse on their path to malignant transformation. In this Perspective, I discuss two recent publications (1, 2) that deal with the durability of senescence. These findings are of interest not only to those who study aging, but to those who study cancer as well.
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http://dx.doi.org/10.1126/sageke.2003.33.pe24 | DOI Listing |
Int Med Case Rep J
January 2025
Department of Dermatology and Venereology, Faculty of Medicine, Udayana University/Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar, Bali, Indonesia.
Gynecomastia is an enlargement of the breasts in men, which is usually benign but can also manifest as a result of malignancies, and can be either unilateral or bilateral. Pseudogynecomastia is male breast enlargement due to excessive fat, while true gynecomastia is a proliferation of glandular tissue. Gynecomastia is common in infants, adolescents, and elderly men, with the most common cause is related to hormonal changes associated with aging.
View Article and Find Full Text PDFCan J Psychiatry
January 2025
Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Background: Late-life depression (LLD) is often accompanied by cognitive impairment, which may persist despite antidepressant treatment. Repetitive transcranial magnetic stimulation (rTMS) is an efficacious treatment for depression, with potential benefits on cognitive functioning. However, research on cognitive effects is inconclusive, relatively sparse in LLD, and predominantly focused on group-level cognitive changes.
View Article and Find Full Text PDFJ Gerontol B Psychol Sci Soc Sci
January 2025
College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Objectives: A growing body of research has identified associations between family size and cognition in older adults. These studies largely focus on older adults' own fertility history instead of sibship size, defined as one's number of siblings. Sibship size may impact cognitive development during early childhood, creating differences that may persist into late-life.
View Article and Find Full Text PDFDisabil Rehabil
January 2025
Centre for Aging SMART at Vancouver Coastal Health, Vancouver, BC, Canada.
Purpose: Mental health conditions after mild traumatic brain injury (mTBI) are common and can complicate injury outcomes, but are under-treated. According to the Common Sense Model of Self-Regulation, the way patients perceive their health conditions can influence the way they manage them, including if, when, and how they seek treatment. This study explored how individuals perceive persistent symptoms after mTBI, in order to develop a grounded theory about what motivates and demotivates them to seek mental health treatment after their injury.
View Article and Find Full Text PDFSSM Popul Health
March 2025
Department of Sociology, Purdue University, United States.
Although socioeconomic status is salient for health and well-being across the life course, previous research indicates that the social gradient in health is racialized and that Black adults experience diminishing health returns on higher socioeconomic status. We extend this literature by examining whether there are diminishing physiological health returns on intergenerational mobility groups for Black adults and, if so, whether diminishing health returns vary across age. We use six waves of data from the Health and Retirement Study (N = 11,846) and mixed effects models; and average marginal effects are used to interpret the race by intergenerational mobility interaction.
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