Many nurse practitioners (NPs) practice in emergency and urgent-care settings, and far more practice in remote settings. NPs in each of these settings should be familiar with the assessment, stabilization, and treatment of patients who seek treatment for suspected intentional or accidental poisoning. This month's clinical practice guideline (CPG) column reviews the "Clinical Policy for the Initial Approach to Patients Presenting With Acute Toxic Ingestion or Dermal or Inhalation Exposure."

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1745-7599.2003.tb01309.xDOI Listing

Publication Analysis

Top Keywords

acute toxic
8
toxic ingestion
8
ingestion dermal
8
dermal inhalation
8
policy acute
4
inhalation exposure
4
exposure nurse
4
nurse practitioners
4
practitioners nps
4
nps practice
4

Similar Publications

Alien toxic toads suppress individual growth and phenotypic development of native predatory salamanders.

Oecologia

January 2025

Tomakomai Experimental Forest, Field Science Center for Northern Biosphere, Hokkaido University, Takaoka, Tomakomai, Hokkaido, 053-0035, Japan.

Alien species can influence populations of native species through individual-level effects such as predation, competition, and poisoning. For alien species that possess strong defensive chemicals, poisoning is one of the most powerful mechanisms of individual-level effects on native biota. Although toxic alien species could potentially negatively affect survival (lethal effects) or life history traits (sub-lethal effects) of native predators via poisoning, previous studies have mainly focused on acute lethal effects.

View Article and Find Full Text PDF

In modern agriculture, control of insect pests is achieved by using insecticides that can also have lethal and sublethal effects on beneficial non-target organisms. Here, we investigate acute toxicity and sublethal effects of four insecticides on the males' sex pheromone response and the female host finding ability of the Drosophila parasitoid Leptopilina heterotoma. The nicotinic acetylcholine receptor antagonists acetamiprid, flupyradifurone and sulfoxaflor, as well as the acetylcholinesterase inhibitor dimethoate were applied topically as acetone solutions.

View Article and Find Full Text PDF

Given the need to reduce animal testing for environmental risk assessment, we aim to develop a fish invitrome, an alternative fish modular framework capable of predicting chemical toxicity in fish without the use of animals. The central module of the framework is the validated RTgill-W1 cell line assay that predicts fish acute toxicity of chemicals (Organization for Economic Cooperation and Development Test Guideline (OECD TG) 249). Expanding towards prediction of chronic toxicity, the fish invitrome includes two other well-advanced modules for chemical bioaccumulation/biotransformation and inhibition of fish growth.

View Article and Find Full Text PDF

Synthesis and biological evaluation of new dual APN/NEP inhibitors as potent analgesics.

Bioorg Chem

January 2025

School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. Electronic address:

An alternative approach for the management of acute and chronic pains involves prolonging the half-life of endogenous opiates, such as enkephalins that are released in response to nociceptive stimuli. This can be achieved through the inhibition of enzymatic pathways responsible for the hydrolysis of these peptides, particularly targeting Aminopeptidase N (APN) and Neutral Endopeptidase (NEP). In this study, we designed and synthesized a series of dual enkephalinase inhibitors (DENKIs) targeting both APN and NEP as novel analgesic treatments.

View Article and Find Full Text PDF

Evaluation of interspecies correlation estimation models to increase taxonomic diversity while reducing reliance on animal testing for chemicals evaluated under the Toxic Substances Control Act.

Integr Environ Assess Manag

January 2025

Office of Chemical Safety Office Pollution Prevention, Office of Pollution Prevention and Toxics, US Environmental Protection Agency, Washington, DC, United States.

The U.S. Environmental Protection Agency is committed to the implementation of new approach methodologies (NAMs) to enhance the scientific basis for chemical hazard assessments.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!