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Preparation and anti-inflammation activity of λ-carrageenan oligosaccharides degraded by a novel λ-carrageenase Car3193.
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December 2024
Key Lab of Ecological Environment Science and Technology, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China. Electronic address:
To date, less attention has been paid to λ-carrageenases and their enzymatic hydrolysates than to κ- and ι-carrageenases and their hydrolysates. In this study, a Gram-negative strain Polaribacter sp. NJDZ03 was isolated from the surface of an Antarctic macroalga, Desmarestia sp.
View Article and Find Full Text PDFVPO1 Promotes Programmed Necrosis of Cardiomyocytes in Rats with Chronic Heart Failure by Upregulating CYLD.
Front Biosci (Landmark Ed)
December 2024
Department of Cardiovascular Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, 410008 Changsha, Hunan, China.
Background: Chronic heart failure (CHF) is a serious cardiovascular condition. Vascular peroxidase 1 (VPO1) is associated with various cardiovascular diseases, yet its role in CHF remains unclear. This research aims to explore the involvement of VPO1 in CHF.
View Article and Find Full Text PDFDisulfide bonds-driven assembly and structural complexity of PTX3: High-resolution structures insights into multimeric architecture.
Int J Biol Macromol
December 2024
Southern University of Science and Technology, Shenzhen 518055, China; Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. Electronic address:
Pentraxin-3 (PTX3) is a multifunctional pattern-recognition molecule that is essential for immune defense, pathogen recognition, and complement activation. PTX3 is stored as a monomer in neutrophil granules, and assembles into higher-order oligomers upon immune activation, thereby enhancing its antimicrobial function. The mechanism underlying this assembly remains elusive.
View Article and Find Full Text PDFReceptor-independent regulation of Gα13 by alpha-1-antitrypsin C-terminal peptides.
J Biol Chem
December 2024
Department of Biosystems Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan; Department of Mammalian and Regulatory Networks, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan; Department of Homeostatic Medicine, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Yushima Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address:
Alpha-1-antitrypsin (AAT), a circulating serine protease inhibitor, is an acute inflammatory response protein with anti-inflammatory functions. The C-terminal peptides of AAT are found in various tissues and have been proposed as putative bioactive peptides with multiple functions, but its mechanism of action remains unclear. We previously reported that a mouse AAT C-terminal peptide of 35 amino acids (mAAT-C) penetrates plasma membrane and associates guanine nucleotide-binding protein subunit alpha 13 (Gα13).
View Article and Find Full Text PDFAdvances of NAT10 in diseases: insights from dual properties as protein and RNA acetyltransferase.
Cell Biol Toxicol
December 2024
Department of Laboratory Medicine, Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, 511518, Guangdong, China.
N-acetyltransferase 10 (NAT10) is a member of the Gcn5-related N-acetyltransferase (GNAT) family and it plays a crucial role in various cellular processes, such as regulation of cell mitosis, post-DNA damage response, autophagy and apoptosis regulation, ribosome biogenesis, RNA modification, and other related pathways through its intrinsic protein acetyltransferase and RNA acetyltransferase activities. Moreover, NAT10 is closely associated with the pathogenesis of tumors, Hutchinson-Gilford progeria syndrome (HGPS), systemic lupus erythematosus, pulmonary fibrosis, depression and host-pathogen interactions. In recent years, mRNA acetylation has emerged as a prominent focus of research due to its pivotal role in regulating RNA stability and translation.
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